AIM: To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH). METHODS: Twenty-eight patients with NASH and 11 with simple fatty liver disease (FL) were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18-immunopositive cells, and homeostasis model assessment of IR (HOMA-IR), respectively. The correlations of these factors with NASH were elucidated. RESULTS: Significant development of hepatic neovascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18 expression and HOMA-R were significantly increased in NASH as compared with FL and healthy liver. Furthermore, CK-18 and HOMA-IR were also positively correlated with the degree of neovascularization. CONCLUSION: These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH. 2009 The WJG Press and Baishideng. All rights reserved.
AIM: To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH). METHODS: Twenty-eight patients with NASH and 11 with simple fatty liver disease (FL) were enrolled in this study and underwent clinicopathological examination. The measures of angiogenesis, CK-18, and IR employed were CD34-immunopositive vessels, CK-18-immunopositive cells, and homeostasis model assessment of IR (HOMA-IR), respectively. The correlations of these factors with NASH were elucidated. RESULTS: Significant development of hepatic neovascularization was observed only in NASH, whereas almost no neovascularization could be observed in FL and healthy liver. The degree of angiogenesis was almost parallel to liver fibrosis development, and both parameters were positively correlated. Similarly, CK-18 expression and HOMA-R were significantly increased in NASH as compared with FL and healthy liver. Furthermore, CK-18 and HOMA-IR were also positively correlated with the degree of neovascularization. CONCLUSION: These results indicate that the crosstalk between angiogenesis, CK-18, and IR may play an important role in the onset and progression of NASH. 2009 The WJG Press and Baishideng. All rights reserved.
Authors: Jesús Medina; Luis Caveda; Paloma Sanz-Cameno; Alicia G Arroyo; Samuel Martín-Vílchez; Pedro L Majano; Luisa García-Buey; Francisco Sánchez-Madrid; Ricardo Moreno-Otero Journal: J Hepatol Date: 2003-05 Impact factor: 25.083
Authors: H Yoshiji; S Kuriyama; J Yoshii; Y Ikenaka; R Noguchi; D J Hicklin; Y Wu; K Yanase; T Namisaki; M Yamazaki; H Tsujinoue; H Imazu; T Masaki; H Fukui Journal: Gut Date: 2003-09 Impact factor: 23.059
Authors: Ariel E Feldstein; Anna Wieckowska; A Rocio Lopez; Yao-Chang Liu; Nizar N Zein; Arthur J McCullough Journal: Hepatology Date: 2009-10 Impact factor: 17.425
Authors: M R Sierra-Honigmann; A K Nath; C Murakami; G García-Cardeña; A Papapetropoulos; W C Sessa; L A Madge; J S Schechner; M B Schwabb; P J Polverini; J R Flores-Riveros Journal: Science Date: 1998-09-11 Impact factor: 47.728
Authors: S Lefere; F Van de Velde; L Devisscher; M Bekaert; S Raevens; X Verhelst; Y Van Nieuwenhove; M Praet; A Hoorens; C Van Steenkiste; H Van Vlierberghe; B Lapauw; A Geerts Journal: Int J Obes (Lond) Date: 2017-05-02 Impact factor: 5.095
Authors: Davide Povero; Akiko Eguchi; Ingrid R Niesman; Nektaria Andronikou; Xavier de Mollerat du Jeu; Anny Mulya; Michael Berk; Milos Lazic; Samjana Thapaliya; Maurizio Parola; Hemal H Patel; Ariel E Feldstein Journal: Sci Signal Date: 2013-10-08 Impact factor: 8.192