AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of cerulean-induced acute pancreatitis (AP). METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 microg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-alpha levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased significantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathological results and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-alpha concentration was nearly the same in the CAPE and placebo groups. CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of beneficial effects of CAPE before clinical usage of this agent. 2009 The WJG Press and Baishideng. All rights reserved.
AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of cerulean-induced acute pancreatitis (AP). METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 microg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-alpha levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased significantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathological results and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-alpha concentration was nearly the same in the CAPE and placebo groups. CONCLUSION:CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of beneficial effects of CAPE before clinical usage of this agent. 2009 The WJG Press and Baishideng. All rights reserved.
Authors: E Vaquero; I Gukovsky; V Zaninovic; A S Gukovskaya; S J Pandol Journal: Am J Physiol Gastrointest Liver Physiol Date: 2001-06 Impact factor: 4.052
Authors: Richard T Ethridge; Dai H Chung; Michele Slogoff; Richard A Ehlers; Mark R Hellmich; Srinivasan Rajaraman; Hiroshi Saito; Tatsuo Uchida; B Mark Evers Journal: Gastroenterology Date: 2002-10 Impact factor: 22.682
Authors: Elaine Liu; Kevin Lewis; Hiba Al-Saffar; Catherine M Krall; Anju Singh; Vladimir A Kulchitsky; Joshua J Corrigan; Christopher T Simons; Scott R Petersen; Florin M Musteata; Chandra S Bakshi; Andrej A Romanovsky; Timothy J Sellati; Alexandre A Steiner Journal: Am J Physiol Regul Integr Comp Physiol Date: 2012-04-18 Impact factor: 3.619
Authors: Victor Emanuel Miranda Soares; Thiago Inácio Teixeira do Carmo; Fernanda Dos Anjos; Jonatha Wruck; Sarah Franco Vieira de Oliveira Maciel; Margarete Dulce Bagatini; Débora Tavares de Resende E Silva Journal: Mol Cell Biochem Date: 2021-09-16 Impact factor: 3.396
Authors: Andrzej Marciniak; Beata Walczyna; Grażyna Rajtar; Sebastian Marciniak; Andrzej Wojtak; Katarzyna Lasiecka Journal: Oxid Med Cell Longev Date: 2015-12-07 Impact factor: 6.543