OBJECTIVES: To investigate developmental changes in the apparently unaffected contralateral lung by using signal intensity ratios (SIR) and lung volumes (LV), and to search for correlation with clinical outcome. METHODS: Twenty-five fetuses (22-37 weeks' gestation) were examined. Lung/liver signal intensity ratios (LLSIR) were assessed on T1-weighted and T2-weighted sequences for both lungs, then together with LV compared with age-matched controls of 91 fetuses by using the U test. Differences in LLSIRs and lung volumes were correlated with neonatal outcomes. RESULTS: LLSIRs in fetuses with congenital diaphragmatic hernia (CDH) were significantly higher in both lungs on T1-weighted images and significantly lower on T2-weighted images, compared with normals (p < 0.05), increasing on T2-weighted imaging and decreasing on T1-weighted imaging during gestation. Total LV were significantly smaller in the CDH group than in controls (p < 0.05). No significant differences in LLSIR of the two lungs were found. Outcomes correlated significantly with total LV, but not with LLSIR. CONCLUSION: Changes in LLSIR seem to reflect developmental impairment in CDH; however, they provide no additional information in predicting outcome. LV remains the best indicator on fetal MR imaging of neonatal survival in isolated, left-sided CDH.
OBJECTIVES: To investigate developmental changes in the apparently unaffected contralateral lung by using signal intensity ratios (SIR) and lung volumes (LV), and to search for correlation with clinical outcome. METHODS: Twenty-five fetuses (22-37 weeks' gestation) were examined. Lung/liver signal intensity ratios (LLSIR) were assessed on T1-weighted and T2-weighted sequences for both lungs, then together with LV compared with age-matched controls of 91 fetuses by using the U test. Differences in LLSIRs and lung volumes were correlated with neonatal outcomes. RESULTS: LLSIRs in fetuses with congenital diaphragmatic hernia (CDH) were significantly higher in both lungs on T1-weighted images and significantly lower on T2-weighted images, compared with normals (p < 0.05), increasing on T2-weighted imaging and decreasing on T1-weighted imaging during gestation. Total LV were significantly smaller in the CDH group than in controls (p < 0.05). No significant differences in LLSIR of the two lungs were found. Outcomes correlated significantly with total LV, but not with LLSIR. CONCLUSION: Changes in LLSIR seem to reflect developmental impairment in CDH; however, they provide no additional information in predicting outcome. LV remains the best indicator on fetal MR imaging of neonatal survival in isolated, left-sided CDH.
Authors: K Wolfgang Neff; A Kristina Kilian; Thomas Schaible; Eva-Maria Schütz; Karen A Büsing Journal: AJR Am J Roentgenol Date: 2007-12 Impact factor: 3.959
Authors: J Jani; M Cannie; E Done; T Van Mieghem; D Van Schoubroeck; L Gucciardo; S Dymarkowski; J A Deprest Journal: Ultrasound Obstet Gynecol Date: 2007-11 Impact factor: 7.299
Authors: Kevin C Worley; Jodi S Dashe; Robert G Barber; Stephen M Megison; Donald D McIntire; Diane M Twickler Journal: Am J Obstet Gynecol Date: 2008-12-25 Impact factor: 8.661
Authors: J Jani; M Cannie; P Sonigo; Y Robert; O Moreno; A Benachi; P Vaast; E Gratacos; K H Nicolaides; J Deprest Journal: Ultrasound Obstet Gynecol Date: 2008-11 Impact factor: 7.299
Authors: M Cannie; J Jani; C Chaffiotte; P Vaast; P Deruelle; V Houfflin-Debarge; S Dymarkowski; J Deprest Journal: Ultrasound Obstet Gynecol Date: 2008-10 Impact factor: 7.299
Authors: Olivier Boucherat; Alexandra Benachi; Bernadette Chailley-Heu; Marie-Laure Franco-Montoya; Caroline Elie; Jelena Martinovic; Jacques R Bourbon Journal: PLoS Med Date: 2007-07-31 Impact factor: 11.069
Authors: Louis D Le; Sundeep G Keswani; Jacek Biesiada; Foong-Yen Lim; Paul S Kingma; Beth E Haberman; Jason Frischer; Mounira Habli; Timothy M Crombleholme Journal: J Pediatr Surg Date: 2012-01 Impact factor: 2.545
Authors: Timothy C Lee; Foong Y Lim; Sundeep G Keswani; Jason S Frischer; Beth Haberman; Paul S Kingma; Mounira Habli; Ronald K Jaekle; Gina Sharp; Beth Kline-Fath; Eva I Rubio; Maria Calvo; Carolina Guimaraes; Timothy M Crombleholme Journal: J Pediatr Surg Date: 2011-06 Impact factor: 2.545
Authors: Ursula Nemec; Stefan F Nemec; Deborah Krakow; Peter C Brugger; Gustavo Malinger; John M Graham; David L Rimoin; Daniela Prayer Journal: Insights Imaging Date: 2011-02-19