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Literature DB >> 19890318

Cancer: A tumour gene's fatal flaws.

Julian Downward.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2009 PMID： 19890318 DOI： 10.1038/462044a

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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10 in total

1. RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.

Authors: Yuchen Chien; Sungchan Kim; Ron Bumeister; Yueh-Ming Loo; Sung Won Kwon; Cynthia L Johnson; Mirey G Balakireva; Yves Romeo; Levy Kopelovich; Michael Gale; Charles Yeaman; Jacques H Camonis; Yingming Zhao; Michael A White
Journal: Cell Date: 2006-10-06 Impact factor: 41.582

Review 2. Regulation and function of IKK and IKK-related kinases.

Authors: Hans Häcker; Michael Karin
Journal: Sci STKE Date: 2006-10-17

3. Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

Authors: M W Mayo; C Y Wang; P C Cogswell; K S Rogers-Graham; S W Lowe; C J Der; A S Baldwin
Journal: Science Date: 1997-12-05 Impact factor: 47.728

4. NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

Authors: Maya Dajee; Mirella Lazarov; Jennifer Y Zhang; Ti Cai; Cheryl L Green; Alan J Russell; M Peter Marinkovich; Shiying Tao; Qun Lin; Yoshiaki Kubo; Paul A Khavari
Journal: Nature Date: 2003-02-06 Impact factor: 49.962

5. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.

Authors: Claudia Scholl; Stefan Fröhling; Ian F Dunn; Anna C Schinzel; David A Barbie; So Young Kim; Serena J Silver; Pablo Tamayo; Raymond C Wadlow; Sridhar Ramaswamy; Konstanze Döhner; Lars Bullinger; Peter Sandy; Jesse S Boehm; David E Root; Tyler Jacks; William C Hahn; D Gary Gilliland
Journal: Cell Date: 2009-05-29 Impact factor: 41.582

Review 6. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.

Authors: Véronique Baud; Michael Karin
Journal: Nat Rev Drug Discov Date: 2009-01 Impact factor: 84.694

7. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.

Authors: Ji Luo; Michael J Emanuele; Danan Li; Chad J Creighton; Michael R Schlabach; Thomas F Westbrook; Kwok-Kin Wong; Stephen J Elledge
Journal: Cell Date: 2009-05-29 Impact factor: 41.582

8. Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma.

Authors: Etienne Meylan; Alison L Dooley; David M Feldser; Lynn Shen; Erin Turk; Chensi Ouyang; Tyler Jacks
Journal: Nature Date: 2009-10-21 Impact factor: 49.962

9. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.

Authors: David A Barbie; Pablo Tamayo; Jesse S Boehm; So Young Kim; Susan E Moody; Ian F Dunn; Anna C Schinzel; Peter Sandy; Etienne Meylan; Claudia Scholl; Stefan Fröhling; Edmond M Chan; Martin L Sos; Kathrin Michel; Craig Mermel; Serena J Silver; Barbara A Weir; Jan H Reiling; Qing Sheng; Piyush B Gupta; Raymond C Wadlow; Hanh Le; Sebastian Hoersch; Ben S Wittner; Sridhar Ramaswamy; David M Livingston; David M Sabatini; Matthew Meyerson; Roman K Thomas; Eric S Lander; Jill P Mesirov; David E Root; D Gary Gilliland; Tyler Jacks; William C Hahn
Journal: Nature Date: 2009-10-21 Impact factor: 49.962

10. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Authors: Jeffrey A Engelman; Liang Chen; Xiaohong Tan; Katherine Crosby; Alexander R Guimaraes; Rabi Upadhyay; Michel Maira; Kate McNamara; Samanthi A Perera; Youngchul Song; Lucian R Chirieac; Ramneet Kaur; Angela Lightbown; Jessica Simendinger; Timothy Li; Robert F Padera; Carlos García-Echeverría; Ralph Weissleder; Umar Mahmood; Lewis C Cantley; Kwok-Kin Wong
Journal: Nat Med Date: 2008-11-30 Impact factor: 53.440

10 in total

1. Kinase inhibitors: narrowing down the real targets.

Authors: Henrik Daub
Journal: Nat Chem Biol Date: 2010-04 Impact factor: 15.040

2. Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons.

Authors: Anna A Shvedova; Naveena Yanamala; Elena R Kisin; Alexey V Tkach; Ashley R Murray; Ann Hubbs; Madalina M Chirila; Phouthone Keohavong; Lyudmila P Sycheva; Valerian E Kagan; Vincent Castranova
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2013-11-08 Impact factor: 5.464

3. Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.

Authors: Pamela K Kreeger; Yufang Wang; Kevin M Haigis; Douglas A Lauffenburger
Journal: Integr Biol (Camb) Date: 2010-03-08 Impact factor: 2.192

4. NF-κB and cancer: a paradigm of Yin-Yang.

Authors: Gutian Xiao; Jing Fu
Journal: Am J Cancer Res Date: 2010-12-06 Impact factor: 6.166

Review 5. The crosstalk of RAS with the TGF-β family during carcinoma progression and its implications for targeted cancer therapy.

Authors: Michael Grusch; Michaela Petz; Thomas Metzner; Deniz Oztürk; Doris Schneller; Wolfgang Mikulits
Journal: Curr Cancer Drug Targets Date: 2010-12 Impact factor: 3.428