CONTEXT: Plasma-borne angiopoietin-like proteins (ANGPTL) act as endocrine factors on their target tissues. Because ANGPTL3 and ANGPTL4 play important roles in lipid metabolism and the regulation of adiposity in mice, we hypothesized that genetic variability at the ANGPTL3 and ANGPTL4 genes loci might influence lipid metabolism and fat deposition in humans. OBJECTIVE: The aim of the study was to examine the association between ANGPTL3 and ANGPTL4 genetic polymorphisms and metabolic phenotypes in adolescent and adult samples. DESIGN AND PARTICIPANTS: Two independent population-based studies, one composed of 1144 adolescents (mean age, 14.8 +/- 1.4 yr) from nine European countries (the HELENA study) and the other composed of 1155 adults (age range, 35-65 yr) from Northern France (the MONICA Lille study), were genotyped for one ANGPTL3 polymorphism and four ANGPTL4 polymorphisms. RESULTS: The ANGPTL3 rs11207997 polymorphism (minor allele frequency, 0.32) was associated with lower plasma HDL-cholesterol and apolipoprotein A-I levels in both adolescents (P = 0.0004, P = 0.00006, respectively) and adults (P = 0.03, P = 0.02, respectively). The ANGPTL4 rs4076317 polymorphism (minor allele frequency, 0.29) was associated with a higher percentage of body fat (P = 0.02) in adolescents and a higher waist-to-hip ratio (in interaction with the peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism) in adults (P = 0.0004). CONCLUSION: The present study underlines the role of ANGPTL3 in HDL-cholesterol metabolism as early as in adolescence. Our data also suggest possible associations between ANGPTL4 polymorphisms and body fat, but these findings require replication.
CONTEXT: Plasma-borne angiopoietin-like proteins (ANGPTL) act as endocrine factors on their target tissues. Because ANGPTL3 and ANGPTL4 play important roles in lipid metabolism and the regulation of adiposity in mice, we hypothesized that genetic variability at the ANGPTL3 and ANGPTL4 genes loci might influence lipid metabolism and fat deposition in humans. OBJECTIVE: The aim of the study was to examine the association between ANGPTL3 and ANGPTL4 genetic polymorphisms and metabolic phenotypes in adolescent and adult samples. DESIGN AND PARTICIPANTS: Two independent population-based studies, one composed of 1144 adolescents (mean age, 14.8 +/- 1.4 yr) from nine European countries (the HELENA study) and the other composed of 1155 adults (age range, 35-65 yr) from Northern France (the MONICA Lille study), were genotyped for one ANGPTL3 polymorphism and four ANGPTL4 polymorphisms. RESULTS: The ANGPTL3rs11207997 polymorphism (minor allele frequency, 0.32) was associated with lower plasma HDL-cholesterol and apolipoprotein A-I levels in both adolescents (P = 0.0004, P = 0.00006, respectively) and adults (P = 0.03, P = 0.02, respectively). The ANGPTL4rs4076317 polymorphism (minor allele frequency, 0.29) was associated with a higher percentage of body fat (P = 0.02) in adolescents and a higher waist-to-hip ratio (in interaction with the peroxisome proliferator-activated receptor gammaPro12Ala polymorphism) in adults (P = 0.0004). CONCLUSION: The present study underlines the role of ANGPTL3 in HDL-cholesterol metabolism as early as in adolescence. Our data also suggest possible associations between ANGPTL4 polymorphisms and body fat, but these findings require replication.
Authors: Bahar Mikhak; Shantel Weinsheimer; Ludmila Pawlikowska; Annie Poon; Pui-Yan Kwok; Michael T Lawton; Yongmei Chen; Jonathan G Zaroff; Stephen Sidney; Charles E McCulloch; William L Young; Helen Kim Journal: Cerebrovasc Dis Date: 2011-01-07 Impact factor: 2.762
Authors: Marius R Robciuc; Jussi Naukkarinen; Alfredo Ortega-Alonso; Henna Tyynismaa; Taneli Raivio; Aila Rissanen; Jaakko Kaprio; Christian Ehnholm; Matti Jauhiainen; Kirsi H Pietiläinen Journal: J Lipid Res Date: 2011-05-19 Impact factor: 5.922
Authors: Karianne Solaas; Vanessa Legry; Kjetil Retterstol; Paul R Berg; Kirsten B Holven; Jean Ferrières; Philippe Amouyel; Sigbjorn Lien; Javier Romeo; Jara Valtueña; Kurt Widhalm; Jonatan R Ruiz; Jean Dallongeville; Serena Tonstad; Helge Rootwelt; Bente Halvorsen; Marit S Nenseter; Kare I Birkeland; Per M Thorsby; Aline Meirhaeghe; Hilde I Nebb Journal: BMC Med Genet Date: 2010-10-12 Impact factor: 2.103