| Literature DB >> 19889576 |
Silva Holtfreter1, Julia Kolata, Barbara M Bröker.
Abstract
This review provides an overview of the antibody response against Staphylococcus aureus, which challenges the adaptive immune system with a broad and highly variable antigen repertoire. The mechanisms by which antibodies shape the interaction between S. aureus and its host are introduced, and evidence for a role of adaptive immunity in the protection against S. aureus is discussed. Techniques are now available to map the core and the variable S. aureus immune proteomes, which constitute the knowledge base for the design of effective anti-S. aureus vaccine compositions. This will require coordinated approaches that match the antigen repertoire of an infecting or colonizing S. aureus strain with the individual antibody response directed against it. Copyright 2009 Elsevier GmbH. All rights reserved.Entities:
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Year: 2009 PMID： 19889576 DOI： 10.1016/j.ijmm.2009.10.002
Source DB: PubMed Journal: Int J Med Microbiol ISSN： 1438-4221 Impact factor: 3.473