AIM: To investigate the longitudinal course and prognostic value of amplitude integrated EEG (aEEG) in infants with neonatal sepsis or meningitis. METHODS: Amplitude integrated EEG recordings of 22 infants with sepsis/meningitis were retrospectively evaluated. Mean gestational age was 38 weeks (range: 34-42 weeks). Thirteen infants had meningitis. Survivors were seen for neurological follow-up. Four infants died, two were severely abnormal at 24 months. Amplitude integrated EEG background pattern, sleep wake cycling (SWC) and electrographic seizure activity (EA) were appraised. RESULTS: All infants with continuous low voltage or flat trace on aEEG (n = 4) had an adverse outcome. Low voltage aEEGs (n = 9) had a positive LR (LR+) for an adverse outcome of 5.3 (95% CI: 1.9-14.8) at 6 h and 8.3 (95% CI: 1.3-55) at 24 h after admission. EA was more frequent in infants with adverse outcome (p < 0.01) and had a LR+ for adverse outcome of 10.6 (95% CI: 1.5-76). SWC appeared more frequent in infants with good outcome (p < 0.05). CONCLUSION: Low voltage background pattern, SWC and EA on aEEG are helpful to predict neurological outcome in infants with neonatal sepsis or meningitis.
AIM: To investigate the longitudinal course and prognostic value of amplitude integrated EEG (aEEG) in infants with neonatal sepsis or meningitis. METHODS: Amplitude integrated EEG recordings of 22 infants with sepsis/meningitis were retrospectively evaluated. Mean gestational age was 38 weeks (range: 34-42 weeks). Thirteen infants had meningitis. Survivors were seen for neurological follow-up. Four infants died, two were severely abnormal at 24 months. Amplitude integrated EEG background pattern, sleep wake cycling (SWC) and electrographic seizure activity (EA) were appraised. RESULTS: All infants with continuous low voltage or flat trace on aEEG (n = 4) had an adverse outcome. Low voltage aEEGs (n = 9) had a positive LR (LR+) for an adverse outcome of 5.3 (95% CI: 1.9-14.8) at 6 h and 8.3 (95% CI: 1.3-55) at 24 h after admission. EA was more frequent in infants with adverse outcome (p < 0.01) and had a LR+ for adverse outcome of 10.6 (95% CI: 1.5-76). SWC appeared more frequent in infants with good outcome (p < 0.05). CONCLUSION: Low voltage background pattern, SWC and EA on aEEG are helpful to predict neurological outcome in infants with neonatal sepsis or meningitis.
Authors: Renée A Shellhaas; Joseph W Burns; Fauziya Hassan; Martha D Carlson; John D E Barks; Ronald D Chervin Journal: Sleep Date: 2017-11-01 Impact factor: 5.849
Authors: Maryam Y Naim; J William Gaynor; Jodi Chen; Susan C Nicolson; Stephanie Fuller; Thomas L Spray; Dennis J Dlugos; Robert R Clancy; Livia Vianez Costa; Daniel J Licht; Rui Xiao; Heather Meldrum; Nicholas S Abend Journal: J Thorac Cardiovasc Surg Date: 2015-04-01 Impact factor: 5.209