Literature DB >> 19888742

An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp.

Shunyan Mo1, Aleksej Krunic, Scott D Pegan, Scott G Franzblau, Jimmy Orjala.   

Abstract

Scytoscalarol (1), a antimicrobial sesterterpene bearing a guanidino group, was isolated from the cultured cyanobacterium Scytonema sp. (UTEX 1163) by bioassay-guided fractionation. The chemical structure was determined by spectroscopic analysis including MS and 1D and 2D NMR. Scytoscalarol (1) showed antimicrobial activities against Bacillus anthracis, Staphylococcus aureus, Escherichia coli, Candida albicans, and Mycobacterium tuberculosis with MIC values in the range from 2 to 110 microM.

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Year:  2009        PMID： 19888742      PMCID： PMC2988765          DOI： 10.1021/np900288x

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  17 in total

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  7 in total

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