| Literature DB >> 19888720 |
Lars O Liepold1, Md Joynal Abedin, Emily D Buckhouse, Joseph A Frank, Mark J Young, Trevor Douglas.
Abstract
A DTPA-Gd containing polymer was grown in the interior of a heat shock protein cage resulting in T(1) particle relaxivities of 4200 mM(-1) sec(-1) for the 12 nm particle. Relaxivity parameters were determined, and this analysis suggests that the rotational correlation time has been optimized while the water exchange lifetime is longer than optimal. This synthetic approach holds much promise for the development of next generation contrast agents and this report will aid in their design.Entities:
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Year: 2009 PMID： 19888720 PMCID： PMC3625947 DOI： 10.1021/nl902884p
Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189