S E Mouridsen1, B Rich, T Isager. 1. Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark. sem01@bbh.hosp.dk
Abstract
BACKGROUND: A number of studies have indicated a link between gastrointestinal (GI) diseases and autism spectrum disorders. METHOD: The objective of this study was to compare the prevalence and types of GI diseases in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with GI diseases in 336 matched controls from the general population, based on data from the nationwide Danish National Hospital Register (DNHR). The average observation time was 30.3 years (SD 0.4) (range 27-30 years), and mean age at the end of the observation period was 42.7 years (SD 7.7) (range between 27 and 57 years of age). RESULTS: Of the 118 individuals with IA, 97 (82.2%) had been in contact with a medical hospital (inpatient hospitalization or outpatient visits) during the observation period, compared with 312/336 (92.9%) in the control group (P= 0.001). A similar proportion of members from the case and comparison group had a diagnosis of any GI disease in the DNHR: 30.5% against 30.7%, but the nature of their diseases may be somewhat different. Only diseases of oral cavity were significantly associated with IA: 20.3% against 1.2%, P < 0.0001. Otherwise, specific GI diseases occurred with low frequency in both groups. CONCLUSION: Overall, no evidence was found that patients with IA were more likely than control persons without IA to have defined GI diseases during the 30.3-year observation period.
BACKGROUND: A number of studies have indicated a link between gastrointestinal (GI) diseases and autism spectrum disorders. METHOD: The objective of this study was to compare the prevalence and types of GI diseases in a clinical sample of 118 individuals diagnosed as children with infantile autism (IA) with GI diseases in 336 matched controls from the general population, based on data from the nationwide Danish National Hospital Register (DNHR). The average observation time was 30.3 years (SD 0.4) (range 27-30 years), and mean age at the end of the observation period was 42.7 years (SD 7.7) (range between 27 and 57 years of age). RESULTS: Of the 118 individuals with IA, 97 (82.2%) had been in contact with a medical hospital (inpatient hospitalization or outpatient visits) during the observation period, compared with 312/336 (92.9%) in the control group (P= 0.001). A similar proportion of members from the case and comparison group had a diagnosis of any GI disease in the DNHR: 30.5% against 30.7%, but the nature of their diseases may be somewhat different. Only diseases of oral cavity were significantly associated with IA: 20.3% against 1.2%, P < 0.0001. Otherwise, specific GI diseases occurred with low frequency in both groups. CONCLUSION: Overall, no evidence was found that patients with IA were more likely than control persons without IA to have defined GI diseases during the 30.3-year observation period.
Authors: Matthew J Maenner; Carrie L Arneson; Susan E Levy; Russell S Kirby; Joyce S Nicholas; Maureen S Durkin Journal: J Autism Dev Disord Date: 2012-07
Authors: Bradley J Ferguson; Sarah Marler; Lily L Altstein; Evon Batey Lee; Jill Akers; Kristin Sohl; Aaron McLaughlin; Kaitlyn Hartnett; Briana Kille; Micah Mazurek; Eric A Macklin; Erin McDonnell; Mariah Barstow; Margaret L Bauman; Kara Gross Margolis; Jeremy Veenstra-VanderWeele; David Q Beversdorf Journal: Autism Res Date: 2016-06-20 Impact factor: 5.216
Authors: Phillip Gorrindo; Kent C Williams; Evon B Lee; Lynn S Walker; Susan G McGrew; Pat Levitt Journal: Autism Res Date: 2012-04 Impact factor: 5.216
Authors: Susie Chandler; Iris Carcani-Rathwell; Tony Charman; Andrew Pickles; Tom Loucas; David Meldrum; Emily Simonoff; Peter Sullivan; Gillian Baird Journal: J Autism Dev Disord Date: 2013-12