Literature DB >> 19886902

Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls.

R Biselli1, S Mariotti, V Sargentini, I Sauzullo, M Lastilla, F Mengoni, V Vanini, E Girardi, D Goletti, R D' Amelio, R Nisini.   

Abstract

Effective control of tuberculosis (TB) includes discrimination of subjects with active TB from individuals with latent TB infection (LTBI). As distinct interferon (IFN)-gamma and interleukin (IL)-2 profiles of antigen-specific T-cells have been associated with different clinical stages and antigen loads in several viral and bacterial diseases, we analysed these cytokines in TB using a modified QuantiFERON-TB Gold In Tube test. Detection of IL-2 in addition to IFN-gamma distinguishes not only Mycobacterium tuberculosis-infected subjects from healthy controls, but also individuals with LTBI from active TB patients. This may help to improve diagnostic tests for TB.

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Year:  2009        PMID： 19886902     DOI： 10.1111/j.1469-0691.2009.03104.x

Source DB:  PubMed          Journal:  Clin Microbiol Infect        ISSN： 1198-743X            Impact factor:   8.067


  42 in total

1.  Multicytokine detection improves latent tuberculosis diagnosis in health care workers.

Authors:  Pierre-Alain Rubbo; Nicolas Nagot; Vincent Le Moing; Marylène Brabet; Arnaud Bourdin; Erika Nogué; Karine Bolloré; Jean-Pierre Vendrell; Philippe Van De Perre; Edouard Tuaillon
Journal:  J Clin Microbiol       Date:  2012-03-07       Impact factor: 5.948

2.  Use of antigen-specific interleukin-2 to differentiate between cattle vaccinated with Mycobacterium bovis BCG and cattle infected with M. bovis.

Authors:  Shelley G Rhodes; Lucy C McKinna; Sabine Steinbach; Gilly S Dean; Bernardo Villarreal-Ramos; Adam O Whelan; C Pirson; Gareth J Jones; Derek Clifford; H Martin Vordermeier
Journal:  Clin Vaccine Immunol       Date:  2013-10-30

3.  Endogenously activated interleukin-4 differentiates disease progressors and non-progressors in tuberculosis susceptible families: a 2-year biomarkers follow-up study.

Authors:  Rabia Hussain; Najeeha Talat; Ambreen Ansari; Firdaus Shahid; Zahra Hasan; Ghaffar Dawood
Journal:  J Clin Immunol       Date:  2011-07-14       Impact factor: 8.317

Review 4.  Diagnostic accuracy of IL-2 for the diagnosis of latent tuberculosis: a systematic review and meta-analysis.

Authors:  S Mamishi; B Pourakbari; M Teymuri; P-A Rubbo; E Tuaillon; A A Keshtkar; S Mahmoudi
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2014-07-04       Impact factor: 3.267

Review 5.  Addressing the tuberculosis-depression syndemic to end the tuberculosis epidemic.

Authors:  A C Sweetland; A Kritski; M A Oquendo; M E Sublette; A Norcini Pala; L R Batista Silva; A Karpati; E C Silva; M O Moraes; J R Lapa E Silva; M L Wainberg
Journal:  Int J Tuberc Lung Dis       Date:  2017-08-01       Impact factor: 2.373

Review 6.  Biomarkers for Detecting Resilience against Mycobacterial Disease in Animals.

Authors:  Kathryn Wright; Karren Plain; Auriol Purdie; Bernadette M Saunders; Kumudika de Silva
Journal:  Infect Immun       Date:  2019-12-17       Impact factor: 3.441

Review 7.  The impact of mucosal infections on acquisition and progression of tuberculosis.

Authors:  S Perry; R Hussain; J Parsonnet
Journal:  Mucosal Immunol       Date:  2011-03-16       Impact factor: 7.313

8.  Characterization of Th1- and Th2-type immune response in human multidrug-resistant tuberculosis.

Authors:  Q Tan; W P Xie; R Min; G Q Dai; C-C Xu; H Q Pan; C D Miao; Z Yang; W G Xu; H Wang
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-10-25       Impact factor: 3.267

9.  Effect of chemotherapy on whole-blood cytokine responses to Mycobacterium tuberculosis antigens in a small cohort of patients with pulmonary tuberculosis.

Authors:  Sylvie Bertholet; David J Horne; Elsa M Laughlin; Margery Savlov; Ines Tucakovic; Rhea N Coler; Masahiro Narita; Steven G Reed
Journal:  Clin Vaccine Immunol       Date:  2011-06-29

10.  Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining.

Authors:  Steven G Smith; Maeve K Lalor; Patricia Gorak-Stolinska; Rose Blitz; Natalie E R Beveridge; Andrew Worth; Helen McShane; Hazel M Dockrell
Journal:  BMC Immunol       Date:  2010-07-07       Impact factor: 3.615
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