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Literature DB >> 19886810

Cohesin: its roles and mechanisms.

Abstract

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.

Entities: Chemical Mutation

Mesh：

Substances：

Year: 2009 PMID： 19886810 DOI： 10.1146/annurev-genet-102108-134233

Source DB: PubMed Journal: Annu Rev Genet ISSN： 0066-4197 Impact factor: 16.830

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Cited

469 in total

Review 1. Polyteny: still a giant player in chromosome research.

Authors: Benjamin M Stormo; Donald T Fox
Journal: Chromosome Res Date: 2017-08-04 Impact factor: 5.239

2. Condensin association with histone H2A shapes mitotic chromosomes.

Authors: Kenji Tada; Hiroaki Susumu; Takeshi Sakuno; Yoshinori Watanabe
Journal: Nature Date: 2011-06-01 Impact factor: 49.962

3. Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction.

Authors: Diana Braunholz; Melanie Hullings; María Concepcion Gil-Rodríguez; Christopher T Fincher; Mark B Mallozzi; Elizabeth Loy; Melanie Albrecht; Maninder Kaur; Janusz Limon; Abhinav Rampuria; Dinah Clark; Antonie Kline; Andreas Dalski; Juliane Eckhold; Andreas Tzschach; Raoul Hennekam; Gabriele Gillessen-Kaesbach; Jolanta Wierzba; Ian D Krantz; Matthew A Deardorff; Frank J Kaiser
Journal: Eur J Hum Genet Date: 2011-09-21 Impact factor: 4.246

4. Cohesin plays a dual role in gene regulation and sister-chromatid cohesion during meiosis in Saccharomyces cerevisiae.

Authors: Weiqiang Lin; Mian Wang; Hui Jin; Hong-Guo Yu
Journal: Genetics Date: 2011-01-26 Impact factor: 4.562

Cohesin: its roles and mechanisms.

Review 1. Polyteny: still a giant player in chromosome research.

2. Condensin association with histone H2A shapes mitotic chromosomes.

3. Isolated NIBPL missense mutations that cause Cornelia de Lange syndrome alter MAU2 interaction.

4. Cohesin plays a dual role in gene regulation and sister-chromatid cohesion during meiosis in Saccharomyces cerevisiae.

5. The fractal globule as a model of chromatin architecture in the cell.

6. Is cohesin required for spindle-pole-body/centrosome cohesion?

7. Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.

8. Pds5 promotes cohesin acetylation and stable cohesin-chromosome interaction.

9. Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.

Review 10. Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.