| Literature DB >> 19886748 |
Robert A Floyd1, Rheal A Towner, Dee Wu, Andrew Abbott, Rebecca Cranford, Dan Branch, Wei-Xing Guo, Steven B Foster, Inna Jones, Rajib Alam, Danny Moore, Toby Allen, Mark Huycke.
Abstract
Abstract The nitrones of alpha-phenyl-tert-butyl nitrone (PBN) and 4-hydroxyl-PBN (4-OH-PBN) that have anti-cancer activity in models of liver cancer and glioblastomas were tested in the ApcMin/+ mouse model. Mice were administered PBN and 4-OH-PBN in drinking water and intestinal tumour size and number assessed after 3-4 months. Throughout the experiment, contrast-enhanced magnetic resonance imaging (MRI) was used to monitor colon tumours. MRI data showed a time-dependent significant increase in total colonic signal intensity in sham-treated mice, but a significant decrease for PBN-treated mice and slight decrease for 4-OHPBN treated mice, probably due to the limited water solubility of 4-OH-PBN. Final pathological and percentage survival data agreed with the MRI data. PBN had little effect on oxaliplatin-mediated killing of HCT116 colon cancer cells and caused only a slight decrease in the amount of active fraction caspase 3 in oxaliplatin-treated cells. PBN has significant anti-cancer activity in this model of intestinal neoplasia.Entities:
Mesh：
Substances：
Year: 2010 PMID： 19886748 PMCID： PMC2884269 DOI： 10.3109/10715760903321796
Source DB: PubMed Journal: Free Radic Res ISSN： 1029-2470