Sickle cell haemoglobin, thalassaemia and G-6-PD enzyme deficiency genes in Garasiya tribe inhabited malaria endemic areas of Sirohi District, Rajasthan (India).

Venous blood samples of 368 apparently healthy and unrelated adult individuals (both male and female) belonging to a primitive tribe, Garasiya inhabitating malaria hyperendemic areas of Sirohi district, Rajasthan (India) were investigated by standard and recommended techniques for evidence of erythrocyte genetic disorders; sickle cell haemoglobin, beta-thalassaemia syndromes and glucose-6-phosphate dehydrogenase (G-6-PD) enzyme deficiency (Gd). Sickle cell genes encountered in 23 (6.25%) Garasiya tribals. Of these, 22 (5.97%) showed heterozygous sickle cell gene(Hb-AS or trait) and one (0.27%) homozygous form (Hb-SS or sickle cell disease). beta-thalassaemia syndromes were observed in 30 (8.15%) subjects; 28 (7.60%) beta-thalassaemia traits (beta-thal.) and 2 (0.54%) HbS-thalassaemia (HbS-thal.). Gd was found in 56 (15.21%) subjects. Except these mutant genes no other erythrocyte abnormal genes were encountered in Garasiya tribe. A high incidence or prevalence of these red cell mutant genes in relation to malaria is discussed in the present communication.