BACKGROUND: The aim of this study was to evaluate the significance of nuclear factor-kappa B (NF-kappaB) expression as a marker of radioresistance in early-stage laryngeal cancer. METHODS: Thirty-five patients with local recurrence and 70 case-matched patients without local recurrence were entered in this study. NF-kappaB expression was compared with Bcl-2 and epidermal growth factor (EGF) receptor expression by immunohistochemistry, using pretreatment biopsy specimens. The prognostic value of NF-kappaB was also evaluated. Twenty-nine recurrent tumors were compared with pretreatment tumors. RESULTS: NF-kappaB expression in pretreatment tumors significantly correlated with local tumor control (p = .01), but bcl-2 and EGF receptor expression did not. Only NF-kappaB expression showed prognostic significance for local tumor control in both univariate and multivariate analyses (p = .008 and .04, respectively). NF-kappaB expression was markedly enhanced in 23 of 29 (80%) recurrent tumors. CONCLUSION: NF-kappaB expression may be a novel marker of radioresistance in early-stage laryngeal cancer.
BACKGROUND: The aim of this study was to evaluate the significance of nuclear factor-kappa B (NF-kappaB) expression as a marker of radioresistance in early-stage laryngeal cancer. METHODS: Thirty-five patients with local recurrence and 70 case-matched patients without local recurrence were entered in this study. NF-kappaB expression was compared with Bcl-2 and epidermal growth factor (EGF) receptor expression by immunohistochemistry, using pretreatment biopsy specimens. The prognostic value of NF-kappaB was also evaluated. Twenty-nine recurrent tumors were compared with pretreatment tumors. RESULTS:NF-kappaB expression in pretreatment tumors significantly correlated with local tumor control (p = .01), but bcl-2 and EGF receptor expression did not. Only NF-kappaB expression showed prognostic significance for local tumor control in both univariate and multivariate analyses (p = .008 and .04, respectively). NF-kappaB expression was markedly enhanced in 23 of 29 (80%) recurrent tumors. CONCLUSION:NF-kappaB expression may be a novel marker of radioresistance in early-stage laryngeal cancer.
Authors: Dirk Rades; Stefan Huttenlocher; Nina D Seibold; Maximilian P Gebhard; Christoph Thorns; Katrin Hasselbacher; Barbara Wollenberg; Steven E Schild Journal: BMC Cancer Date: 2015-03-06 Impact factor: 4.430
Authors: Maartje G Noordhuis; Emiel A Kop; Bert van der Vegt; Johannes A Langendijk; Bernard F A M van der Laan; Ed Schuuring; Geertruida H de Bock Journal: Clin Otolaryngol Date: 2020-04-23 Impact factor: 2.597