Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population.

Recent genome-wide association studies have provided an important resource for furthering our understanding of type 2 diabetes mellitus (T2DM) disease mechanisms. Most of these T2DM gene loci affect insulin secretion. We examined the association of rs7903146 variant in the transcription factor 7 like 2 gene (TCF7L2) with T2DM in 333 Palestinian subjects (219 were type 2 diabetic patients and 114 normoglycemic subjects). The rs7903146 variant of TCF7L2 significantly increased T2DM risk with an allelic odds ratio of 3.34 (95% CI [1.99-5.60], P < 0.0001). No significant association was observed between TCF7L2 genotypes and covariates of age, gender and BMI or any tested metabolic trait (total cholesterol and fasting plasma glucose) in both diabetic and nondiabetic individuals (P > 0.05). Among the diabetic group, the TT genotype carrier have earlier age at diagnosis compared with CC and CT carriers (P = 0.013). This is the first study conducted on this gene in the Palestinian population and provides valuable information for comparison with other ethnic groups.