| Literature DB >> 1988508 |
F A Plummer1, J N Simonsen, D W Cameron, J O Ndinya-Achola, J K Kreiss, M N Gakinya, P Waiyaki, M Cheang, P Piot, A R Ronald.
Abstract
In a study of human immunodeficiency virus type 1 (HIV-1)-uninfected African prostitutes, 83 (67%) of 124 seroconverted to HIV-1. Oral contraceptive use (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.1-8.6; P less than .03), genital ulcers (mean annual episodes, 1.32 +/- 0.55 in seroconverting women vs. 0.48 +/- 0.21 in seronegative women; P less than .02) and Chlamydia trachomatis infections (OR, 3.6; CI, 1.3-11.0; P less than .02) were associated with increased risk of HIV-1 infection. Condom use reduced the risk of HIV-1 infection (OR, 0.11; CI, 0.05-0.27; P less than .0001). Stepwise logistic regression analysis confirmed independent associations between HIV-1 infection and oral contraceptive use, condom use, genital ulcers, and C. trachomatis. The presence of other sexually transmitted diseases may in part explain the heterosexual HIV-1 epidemic in Africa and may represent important targets for intervention to control HIV-1 infection.Entities:
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Year: 1991 PMID： 1988508 DOI： 10.1093/infdis/163.2.233
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226