Literature DB >> 19885013

The Inhibitory Effect of Quercetin-3-O-beta-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats.

Young Sil Min1, Se Eun Lee, Seung Tae Hong, Hyun Sik Kim, Byung-Chul Choi, Sang Soo Sim, Wan Kyun Whang, Uy Dong Sohn.   

Abstract

It was evaluated the inhibitory action of quercetin-3-O-beta-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.

Entities:  

Keywords:  Gastritis; Lipid peroxidation; Quercetin-3-O-β-D-glucuronopyranoside; Reflux esophagitis

Year:  2009        PMID： 19885013      PMCID： PMC2766707          DOI： 10.4196/kjpp.2009.13.4.295

Source DB:  PubMed          Journal:  Korean J Physiol Pharmacol        ISSN： 1226-4512            Impact factor:   2.016


  27 in total

1.  Structure-antioxidant activity relationships of flavonoids and phenolic acids.

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3.  The effects of apigenin-7-O-beta-D-glucuronopyranoside on reflux oesophagitis and gastritis in rats.

Authors:  Y S Min; S H Yim; K L Bai; H J Choi; J H Jeong; H J Song; S Y Park; I Ham; W K Whang; U D Sohn
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4.  Mucosal protective effect of leminoprazole on reflux esophagitis induced in rats.

Authors:  S Okabe; Y Takinami; K Iwata; T Yanagawa
Journal:  Jpn J Pharmacol       Date:  1995-12

5.  Antioxidant activity of quercetin and myricetin in liposomes.

Authors:  M H Gordon; A Roedig-Penman
Journal:  Chem Phys Lipids       Date:  1998-12       Impact factor: 3.329

6.  Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man.

Authors:  P C Hollman; J M van Trijp; M N Buysman; M S van der Gaag; M J Mengelers; J H de Vries; M B Katan
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Review 7.  Bioavailability and health effects of dietary flavonols in man.

Authors:  P C Hollman; M B Katan
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Review 8.  Signal transduction pathways in esophageal and lower esophageal sphincter circular muscle.

Authors:  P Biancani; U D Sohn; H G Rich; K M Harnett; J Behar
Journal:  Am J Med       Date:  1997-11-24       Impact factor: 4.965

9.  Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits.

Authors:  M J Naya; D Pereboom; J Ortego; J O Alda; A Lanas
Journal:  Gut       Date:  1997-02       Impact factor: 23.059

10.  Esophagitis in Sprague-Dawley rats is mediated by free radicals.

Authors:  G J Wetscher; G Perdikis; D H Kretchmar; R G Stinson; D Bagchi; E J Redmond; T E Adrian; R A Hinder
Journal:  Dig Dis Sci       Date:  1995-06       Impact factor: 3.199
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  13 in total

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Review 2.  The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review.

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3.  A Randomized Placebo- Controlled Double Blind Clinical Trial of Quercetin in the Prevention and Treatment of Chemotherapy-Induced Oral Mucositis.

Authors:  Mohammad Mahdi Kooshyar; Pegah Mosannen Mozafari; Maryam Amirchaghmaghi; Atessa Pakfetrat; Parisa Karoos; Mahdokht Rashed Mohasel; Hosein Orafai; Amir Abbas Azarian
Journal:  J Clin Diagn Res       Date:  2017-03-01

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Authors:  Jung Hyun Cho; Sun Young Park; Ho Sung Lee; Wan Kyunn Whang; Uy Dong Sohn
Journal:  Korean J Physiol Pharmacol       Date:  2011-12-27       Impact factor: 2.016

5.  Acute Toxicity and General Pharmacological Action of QGC EXT.

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Journal:  Korean J Physiol Pharmacol       Date:  2012-02-28       Impact factor: 2.016

6.  Protective Effect of ECQ on Rat Reflux Esophagitis Model.

Authors:  Hyeon-Soon Jang; Jeong Hoon Han; Jun Yeong Jeong; Uy Dong Sohn
Journal:  Korean J Physiol Pharmacol       Date:  2012-12-10       Impact factor: 2.016

7.  Inhibitory Effects of ECQ on Indomethacin-Induced Gastric Damage in Rats.

Authors:  Juho Jung; Yoonjin Nam; Uy Dong Sohn
Journal:  Korean J Physiol Pharmacol       Date:  2012-12-10       Impact factor: 2.016

8.  Effect of Lutein on L-NAME-Induced Hypertensive Rats.

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9.  Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats.

Authors:  Se Eun Lee; Hyun Ju Song; Sun Young Park; Yoonjin Nam; Chang Ho Min; Do Yeon Lee; Jun Yeong Jeong; Hyun Su Ha; Hyun-Jung Kim; Wan Kyun Whang; Ji Hoon Jeong; In Kyeom Kim; Hak Rim Kim; Young Sil Min; Uy Dong Sohn
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10.  Gastroprotective effect of the three glucuronopyranoside flavonoids in rats.

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Journal:  Korean J Physiol Pharmacol       Date:  2013-10-17       Impact factor: 2.016
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