Literature DB >> 19884580

Mgmt methylation is a prognostic biomarker in elderly patients with newly diagnosed glioblastoma.

E R Gerstner1, S Yip, D L Wang, D N Louis, A J Iafrate, T T Batchelor.   

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Year:  2009        PMID： 19884580      PMCID： PMC2779003          DOI： 10.1212/WNL.0b013e3181bf9907

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


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  6 in total

1.  Treatment of glioblastoma multiforme in elderly patients. Clinico-therapeutic remarks in 22 patients older than 80 years.

Authors:  Manolo Piccirilli; Simona Bistazzoni; Franco Maria Gagliardi; Alessandro Landi; Antonio Santoro; Felice Giangaspero; Maurizio Salvati
Journal:  Tumori       Date:  2006 Mar-Apr       Impact factor: 2.098

2.  O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells.

Authors:  Mirjam Hermisson; Andrea Klumpp; Wolfgang Wick; Jörg Wischhusen; Georg Nagel; Wynand Roos; Bernd Kaina; Michael Weller
Journal:  J Neurochem       Date:  2006-01-09       Impact factor: 5.372

3.  Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

Authors:  M Esteller; S R Hamilton; P C Burger; S B Baylin; J G Herman
Journal:  Cancer Res       Date:  1999-02-15       Impact factor: 12.701

4.  MGMT gene silencing and benefit from temozolomide in glioblastoma.

Authors:  Monika E Hegi; Annie-Claire Diserens; Thierry Gorlia; Marie-France Hamou; Nicolas de Tribolet; Michael Weller; Johan M Kros; Johannes A Hainfellner; Warren Mason; Luigi Mariani; Jacoline E C Bromberg; Peter Hau; René O Mirimanoff; J Gregory Cairncross; Robert C Janzer; Roger Stupp
Journal:  N Engl J Med       Date:  2005-03-10       Impact factor: 91.245

Review 5.  Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity.

Authors:  Monika E Hegi; Lili Liu; James G Herman; Roger Stupp; Wolfgang Wick; Michael Weller; Minesh P Mehta; Mark R Gilbert
Journal:  J Clin Oncol       Date:  2008-09-01       Impact factor: 44.544

6.  Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.

Authors:  J C Baer; A A Freeman; E S Newlands; A J Watson; J A Rafferty; G P Margison
Journal:  Br J Cancer       Date:  1993-06       Impact factor: 7.640
  6 in total
  43 in total

1.  Are we ready to demystify age in glioblastoma? Or does older age matter in glioblastoma?

Authors:  Michael Weller; Wolfgang Wick
Journal:  Neuro Oncol       Date:  2011-04       Impact factor: 12.300

Review 2.  Treating glioblastoma in the elderly.

Authors:  Jaime Gállego Pérez-Larraya; Jean-Yves Delattre
Journal:  CNS Oncol       Date:  2012-11

Review 3.  Management of elderly patients with gliomas.

Authors:  Jaime Gállego Pérez-Larraya; Jean-Yves Delattre
Journal:  Oncologist       Date:  2014-10-23

4.  Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide.

Authors:  Giuseppe Minniti; M Salvati; A Arcella; F Buttarelli; A D'Elia; G Lanzetta; V Esposito; S Scarpino; R Maurizi Enrici; F Giangaspero
Journal:  J Neurooncol       Date:  2010-08-05       Impact factor: 4.130

5.  The prognosis of MGMT promoter methylation in glioblastoma patients of different race: a meta-analysis.

Authors:  Haiyu Yang; Danping Wei; Kunxian Yang; Wenru Tang; Ying Luo; Jihong Zhang
Journal:  Neurochem Res       Date:  2014-09-18       Impact factor: 3.996

Review 6.  Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers.

Authors:  Michael Jansen; Stephen Yip; David N Louis
Journal:  Lancet Neurol       Date:  2010-07       Impact factor: 44.182

Review 7.  Treatment of Glioblastoma in the Elderly.

Authors:  Rebecca A Harrison; John F de Groot
Journal:  Drugs Aging       Date:  2018-08       Impact factor: 3.923

Review 8.  Radiation therapy for older adults with glioblastoma: radical treatment, palliative treatment, or no treatment at all?

Authors:  Giuseppe Minniti; Riccardo Maurizi Enrici
Journal:  J Neurooncol       Date:  2014-08-06       Impact factor: 4.130

9.  MGMT promoter methylation and correlation with protein expression in primary central nervous system lymphoma.

Authors:  L Toffolatti; E Scquizzato; S Cavallin; F Canal; M Scarpa; P M Stefani; F Gherlinzoni; A P Dei Tos
Journal:  Virchows Arch       Date:  2014-07-17       Impact factor: 4.064

Review 10.  Relationship between cognitive function and prognosis in glioblastoma.

Authors:  Derek R Johnson; Jeffrey S Wefel
Journal:  CNS Oncol       Date:  2013-03
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