Literature DB >> 19884252

Subtraction by addition: domesticated transposases in programmed DNA elimination.

Jason A Motl1, Douglas L Chalker.   

Abstract

The ciliate Paramecium tetraurelia must eliminate approximately 60,000 short sequences from its genome to generate uninterrupted coding sequences in its somatic macronucleus. In this issue of Genes & Development, Baudry and colleagues (pp. 2478-2483) identify the protein that excises these noncoding sequences: a domesticated piggyBac transposase that has been adapted to remove what are likely the remnants of transposon insertions. This new study reveals how addition of a transposase to small RNA-directed silencing machinery can guide major genome reorganization.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19884252      PMCID： PMC2779744          DOI： 10.1101/gad.1864609

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  43 in total

1.  A developmentally regulated deletion element with long terminal repeats has cis-acting sequences in the flanking DNA.

Authors:  N S Patil; K M Karrer
Journal:  Nucleic Acids Res       Date:  2000-03-15       Impact factor: 16.971

2.  Programmed loss of millions of base pairs from a vertebrate genome.

Authors:  Jeramiah J Smith; Francesca Antonacci; Evan E Eichler; Chris T Amemiya
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-26       Impact factor: 11.205

Review 3.  Developmental genome reorganization in ciliated protozoa: the transposon link.

Authors:  L A Klobutcher; G Herrick
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1997

4.  Cis-acting requirements in flanking DNA for the programmed elimination of mse2.9: a common mechanism for deletion of internal eliminated sequences from the developing macronucleus of Tetrahymena thermophila.

Authors:  J S Fillingham; D Bruno; R E Pearlman
Journal:  Nucleic Acids Res       Date:  2001-01-15       Impact factor: 16.971

5.  Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena.

Authors:  Kazufumi Mochizuki; Noah A Fine; Toshitaka Fujisawa; Martin A Gorovsky
Journal:  Cell       Date:  2002-09-20       Impact factor: 41.582

6.  Flanking regulatory sequences of the Tetrahymena R deletion element determine the boundaries of DNA rearrangement.

Authors:  D L Chalker; A La Terza; A Wilson; C D Kroenke; M C Yao
Journal:  Mol Cell Biol       Date:  1999-08       Impact factor: 4.272

7.  Developmentally regulated chromosome fragmentation linked to imprecise elimination of repeated sequences in paramecia.

Authors:  Anne Le Mouël; Alain Butler; François Caron; Eric Meyer
Journal:  Eukaryot Cell       Date:  2003-10

8.  piggyBac can bypass DNA synthesis during cut and paste transposition.

Authors:  Rupak Mitra; Jennifer Fain-Thornton; Nancy L Craig
Journal:  EMBO J       Date:  2008-03-20       Impact factor: 11.598

9.  A functional role for transposases in a large eukaryotic genome.

Authors:  Mariusz Nowacki; Brian P Higgins; Genevieve M Maquilan; Estienne C Swart; Thomas G Doak; Laura F Landweber
Journal:  Science       Date:  2009-04-16       Impact factor: 47.728

10.  Convergent domestication of pogo-like transposases into centromere-binding proteins in fission yeast and mammals.

Authors:  Claudio Casola; Donald Hucks; Cédric Feschotte
Journal:  Mol Biol Evol       Date:  2007-10-16       Impact factor: 16.240
View more
  2 in total

1.  Lineage-specific expansions of TET/JBP genes and a new class of DNA transposons shape fungal genomic and epigenetic landscapes.

Authors:  Lakshminarayan M Iyer; Dapeng Zhang; Robson F de Souza; Patricia J Pukkila; Anjana Rao; L Aravind
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-07       Impact factor: 11.205

2.  Are we Genomic Mosaics? Variations of the Genome of Somatic Cells can Contribute to Diversify our Phenotypes.

Authors:  P A Astolfi; F Salamini; V Sgaramella
Journal:  Curr Genomics       Date:  2010-09       Impact factor: 2.236
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.