Literature DB >> 19884004

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands.

Ronald C Bernotas1, Schuyler A Antane, Steven E Lenicek, Simon N Haydar, Albert J Robichaud, Boyd L Harrison, Guo Ming Zhang, Deborah Smith, Joseph Coupet, Lee E Schechter.   

Abstract

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT(6) receptor ligands, among which 6f and 6g showed high affinity for 5-HT(6) receptors with K(i)=3.9 and 1.7 nM, respectively.

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Year:  2009        PMID: 19884004     DOI: 10.1016/j.bmcl.2009.10.067

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.

Authors:  Evelyn K Lambe; Stu G Fillman; Maree J Webster; Cynthia Shannon Weickert
Journal:  PLoS One       Date:  2011-07-29       Impact factor: 3.240

  1 in total

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