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Literature DB >> 19883103

Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.

Katherine N Maloney¹, John B Macmillan, Christopher A Kauffman, Paul R Jensen, Antonio G Dipasquale, Arnold L Rheingold, William Fenical.

Abstract

Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2009 PMID： 19883103 PMCID： PMC2820114 DOI： 10.1021/ol901997k

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

7 in total

1. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

Authors: Robert H Feling; Greg O Buchanan; Tracy J Mincer; Christopher A Kauffman; Paul R Jensen; William Fenical
Journal: Angew Chem Int Ed Engl Date: 2003-01-20 Impact factor: 15.336

Review 2. THE QUESTION OF THE EXISTENCE OF SPECIFIC MARINE BACTERIA.

Authors: R A MACLEOD
Journal: Bacteriol Rev Date: 1965-03

Review 3. Bioactive microbial metabolites.

Authors: János Bérdy
Journal: J Antibiot (Tokyo) Date: 2005-01 Impact factor: 2.649

4. Developing a new resource for drug discovery: marine actinomycete bacteria.

Authors: William Fenical; Paul R Jensen
Journal: Nat Chem Biol Date: 2006-12 Impact factor: 15.040

5. WS75624 A and B, new endothelin converting enzyme inhibitors isolated from Saccharothrix sp. No. 75624. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

Authors: Y Tsurumi; H Ueda; K Hayashi; S Takase; M Nishikawa; S Kiyoto; M Okuhara
Journal: J Antibiot (Tokyo) Date: 1995-10 Impact factor: 2.649

6. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors: T Mosmann
Journal: J Immunol Methods Date: 1983-12-16 Impact factor: 2.303

7. B-90063, a novel endothelin converting enzyme inhibitor isolated from a new marine bacterium, Blastobacter sp. SANK 71894.

Authors: S Takaishi; N Tuchiya; A Sato; T Negishi; Y Takamatsu; Y Matsushita; T Watanabe; Y Iijima; H Haruyama; T Kinoshita; M Tanaka; K Kodama
Journal: J Antibiot (Tokyo) Date: 1998-09 Impact factor: 2.649

7 in total

17 in total

1. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

Authors: Kazuya Yamanaka; Kirk A Reynolds; Roland D Kersten; Katherine S Ryan; David J Gonzalez; Victor Nizet; Pieter C Dorrestein; Bradley S Moore
Journal: Proc Natl Acad Sci U S A Date: 2014-01-21 Impact factor: 11.205

2. Bioactive compounds from mangrove derived rare actinobacterium Saccharomonospora oceani VJDS-3.

Authors: Manideepa Indupalli; Vijayalakshmi Muvva; Ushakiranmayi Mangamuri; Rajesh Kumar Munaganti; Krishna Naragani
Journal: 3 Biotech Date: 2018-01-29 Impact factor: 2.406

3. The Antibacterial, Antitumor Activities, and Bioactive Constituents' Identification of Alectra sessiliflora Bacterial Endophytes.

Authors: Mehabo Penistacia Maela; Hendriëtte van der Walt; Mahloro Hope Serepa-Dlamini
Journal: Front Microbiol Date: 2022-07-05 Impact factor: 6.064

10. An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide.

Authors: Liquan Tan; Peng Zhou; Cui Chen; Weibing Liu
Journal: Beilstein J Org Chem Date: 2013-11-28 Impact factor: 2.883

Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.

1. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

Review 2. THE QUESTION OF THE EXISTENCE OF SPECIFIC MARINE BACTERIA.

Review 3. Bioactive microbial metabolites.

4. Developing a new resource for drug discovery: marine actinomycete bacteria.

5. WS75624 A and B, new endothelin converting enzyme inhibitors isolated from Saccharothrix sp. No. 75624. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

6. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

7. B-90063, a novel endothelin converting enzyme inhibitor isolated from a new marine bacterium, Blastobacter sp. SANK 71894.

1. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

2. Bioactive compounds from mangrove derived rare actinobacterium Saccharomonospora oceani VJDS-3.

3. The Antibacterial, Antitumor Activities, and Bioactive Constituents' Identification of Alectra sessiliflora Bacterial Endophytes.

Review 4. Marine antitumor drugs: status, shortfalls and strategies.

Review 5. Immense essence of excellence: marine microbial bioactive compounds.

6. Saccharomonopyrones A-C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490.

Review 7. Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds.

Review 8. Natural products as reservoirs of novel therapeutic agents.

Review 9. A Review: Halogenated Compounds from Marine Actinomycetes.

10. An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide.