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Literature DB >> 19882724

Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.

David Wright¹, Zoltan Ferjentsik¹, Shang-Wei Chong², Xuehui Qiu², Jiang Yun-Jin², Pascale Malapert³, Olivier Pourquié³, Nick Van Hateren⁴, Stuart A Wilson⁴, Claudio Franco⁵, Holger Gerhardt⁵, J Kim Dale¹, Miguel Maroto¹.

Abstract

Somites are formed progressively from the presomitic mesoderm (PSM) in a highly regulated process according to a strict periodicity driven by an oscillatory mechanism. The Notch and Wnt pathways are key components in the regulation of this somitic oscillator and data from Xenopus and zebrafish embryos indicate that the Notch-downstream target Nrarp participates in the regulation of both activities. We have analyzed Nrarp/nrarp-a expression in the PSM of chick, mouse and zebrafish embryos, and we show that it cycles in synchrony with other Notch regulated cyclic genes. In the mouse its transcription is both Wnt- and Notch-dependent, whereas in the chick and fish embryo it is simply Notch-dependent. Despite oscillating mRNA levels, Nrarp protein does not oscillate in the PSM. Finally, neither gain nor loss of Nrarp function interferes with the normal expression of Notch-related cyclic genes. (c) 2009 Wiley-Liss, Inc.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19882724 PMCID： PMC3928721 DOI： 10.1002/dvdy.22139

Source DB: PubMed Journal: Dev Dyn ISSN： 1058-8388 Impact factor: 3.780

57 in total

1. Dynamic expression and essential functions of Hes7 in somite segmentation.

Authors: Y Bessho; R Sakata; S Komatsu; K Shiota; S Yamada; R Kageyama
Journal: Genes Dev Date: 2001-10-15 Impact factor: 11.361

2. Synchronised cycling gene oscillations in presomitic mesoderm cells require cell-cell contact.

Authors: Miguel Maroto; J Kim Dale; Mary-Lee Dequéant; Anne-Cécile Petit; Olivier Pourquié
Journal: Int J Dev Biol Date: 2005 Impact factor: 2.203

3. Mesoderm movement and fate during avian gastrulation and neurulation.

Authors: G C Schoenwolf; V Garcia-Martinez; M S Dias
Journal: Dev Dyn Date: 1992-03 Impact factor: 3.780

Review 4. Epithelial type, ingression, blastopore architecture and the evolution of chordate mesoderm morphogenesis.

Authors: David R Shook; Ray Keller
Journal: J Exp Zool B Mol Dev Evol Date: 2008-01-15 Impact factor: 2.656

Review 5. Amniote somite derivatives.

Authors: Bodo Christ; Ruijin Huang; Martin Scaal
Journal: Dev Dyn Date: 2007-09 Impact factor: 3.780

6. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).

Authors: Yuichi Morohashi; Toshiyuki Kan; Yusuke Tominari; Haruhiko Fuwa; Yumiko Okamura; Naoto Watanabe; Chihiro Sato; Hideaki Natsugari; Tohru Fukuyama; Takeshi Iwatsubo; Taisuke Tomita
Journal: J Biol Chem Date: 2006-03-28 Impact factor: 5.157

7. Organization and development of the tail bud analyzed with the quail-chick chimaera system.

Authors: M Catala; M A Teillet; N M Le Douarin
Journal: Mech Dev Date: 1995-05 Impact factor: 1.882

8. Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors.

Authors: C Leimeister; K Dale; A Fischer; B Klamt; M Hrabe de Angelis; F Radtke; M J McGrew; O Pourquié; M Gessler
Journal: Dev Biol Date: 2000-11-01 Impact factor: 3.582

9. Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation.

Authors: A Aulehla; R L Johnson
Journal: Dev Biol Date: 1999-03-01 Impact factor: 3.582

10. Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling.

Authors: Aki Ishikawa; Satoshi Kitajima; Yu Takahashi; Hiroki Kokubo; Jun Kanno; Tohru Inoue; Yumiko Saga
Journal: Mech Dev Date: 2004-12 Impact factor: 1.882

12 in total

1. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program.

Authors: Ravindra B Chalamalasetty; William C Dunty; Kristin K Biris; Rieko Ajima; Michelina Iacovino; Arica Beisaw; Lionel Feigenbaum; Deborah L Chapman; Jeong Kyo Yoon; Michael Kyba; Terry P Yamaguchi
Journal: Nat Commun Date: 2011-07-12 Impact factor: 14.919

2. Evolutionary plasticity of segmentation clock networks.

Authors: Aurélie J Krol; Daniela Roellig; Mary-Lee Dequéant; Olivier Tassy; Earl Glynn; Gaye Hattem; Arcady Mushegian; Andrew C Oates; Olivier Pourquié
Journal: Development Date: 2011-07 Impact factor: 6.868

3. From the primitive streak to the somitic mesoderm: labeling the early stages of chick embryos using EGFP transfection.

Authors: Haiming Fan; Nobuyuki Sakamoto; Hirohiko Aoyama
Journal: Anat Sci Int Date: 2018-02-09 Impact factor: 1.741

Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.

1. Dynamic expression and essential functions of Hes7 in somite segmentation.

2. Synchronised cycling gene oscillations in presomitic mesoderm cells require cell-cell contact.

3. Mesoderm movement and fate during avian gastrulation and neurulation.

Review 4. Epithelial type, ingression, blastopore architecture and the evolution of chordate mesoderm morphogenesis.

Review 5. Amniote somite derivatives.

6. C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).

7. Organization and development of the tail bud analyzed with the quail-chick chimaera system.

8. Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors.

9. Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation.

10. Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling.

1. The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program.

2. Evolutionary plasticity of segmentation clock networks.

3. From the primitive streak to the somitic mesoderm: labeling the early stages of chick embryos using EGFP transfection.

Review 4. Vertebrate segmentation: from cyclic gene networks to scoliosis.

5. Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes.

6. The chick somitogenesis oscillator is arrested before all paraxial mesoderm is segmented into somites.

Review 7. The segmentation clock mechanism moves up a notch.

8. The period of the somite segmentation clock is sensitive to Notch activity.

9. The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice.

Review 10. Timing embryo segmentation: dynamics and regulatory mechanisms of the vertebrate segmentation clock.