Literature DB >> 19881279

Structures of new phenylbutanoids and nitric oxide production inhibitors from the rhizomes of Zingiber cassumunar.

Seikou Nakamura1, Junko Iwami, Hisashi Matsuda, Hiroko Wakayama, Yutana Pongpiriyadacha, Masayuki Yoshikawa.   

Abstract

The methanolic (MeOH) extract from the rhizomes of Zingiber cassumunar showed nitric oxide (NO) production inhibitory effects induced by lipopolysaccharide (LPS) in mouse peritoneal macrophages. From the MeOH extract, six new phenylbutanoids, phlains I-VI, were isolated together with 16 known constituents. The structures of new phenylbutanoids were determined on the basis of physicochemical and chemical evidence. In addition, the inhibitory effects of the principal constituents on the NO production were examined. Among them, phlain III (IC50=24 microM), (E)-1-(3,4-dimethoxyphenyl)buta-1,3-diene (69 microM), (E)-1-(2,4,5-trimethoxyphenyl)buta-1,3-diene (83 microM), and cassumunaquinone 1 (47 microM) were found to show the inhibitory effects.

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Year:  2009        PMID： 19881279     DOI： 10.1248/cpb.57.1267

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  7 in total

1.  Antiphotoaging properties of Zingiber montanum essential oil isolated by solvent-free microwave extraction against ultraviolet B-irradiated human dermal fibroblasts.

Authors:  Abhiruj Navabhatra; Rawiwan Maniratanachote; Bancha Yingngam
Journal:  Toxicol Res       Date:  2021-10-03

2.  Properties of macerated herbal oil.

Authors:  Fahsai Kantawong; Supawatchara Singhatong; Aomjai Srilamay; Kantarose Boonyuen; Niroot Mooti; Phenphichar Wanachantararak; Thasaneeya Kuboki
Journal:  Bioimpacts       Date:  2017-02-08

3.  Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation.

Authors:  Kazumi Hirano; Miwa Kubo; Yoshiyasu Fukuyama; Masakazu Namihira
Journal:  Int J Mol Sci       Date:  2020-07-05       Impact factor: 5.923

4.  The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS-Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus.

Authors:  Ratchaniporn Kongsui; Napatr Sriraksa; Sitthisak Thongrong
Journal:  Biomed Res Int       Date:  2020-05-25       Impact factor: 3.411

Review 5.  Phytochemicals and Bioactivities of Zingiber cassumunar Roxb.

Authors:  Ah-Reum Han; Hyunyoung Kim; Donglan Piao; Chan-Hun Jung; Eun Kyoung Seo
Journal:  Molecules       Date:  2021-04-19       Impact factor: 4.411

6.  (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.

Authors:  Jisu Park; Heesung Chung; Seung Hyun Bang; Ah-Reum Han; Eun-Kyoung Seo; Sung Eun Chang; Duk-Hee Kang; Eok-Soo Oh
Journal:  PLoS One       Date:  2015-11-04       Impact factor: 3.240

7.  Citrus bergamia: Kinetics of Antimicrobial Activity on Clinical Isolates.

Authors:  Angela Quirino; Valeria Giorgi; Ernesto Palma; Nadia Marascio; Paola Morelli; Angelo Maletta; Francesca Divenuto; Giuseppe De Angelis; Valentina Tancrè; Saverio Nucera; Micaela Gliozzi; Vincenzo Musolino; Cristina Carresi; Vincenzo Mollace; Maria Carla Liberto; Giovanni Matera
Journal:  Antibiotics (Basel)       Date:  2022-03-08
  7 in total

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