Literature DB >> 19879758

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs.

Rita Fürst1, István Zupkó, Agnes Berényi, Gerhard F Ecker, Uwe Rinner.   

Abstract

Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.

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Year:  2009        PMID： 19879758     DOI： 10.1016/j.bmcl.2009.10.064

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Combretastatin A4-β-Galactosyl Conjugates for Ovarian Cancer Prodrug Monotherapy.

Authors:  Tomohiro Doura; Kazuaki Takahashi; Yasumitsu Ogra; Noriyuki Suzuki
Journal:  ACS Med Chem Lett       Date:  2017-01-20       Impact factor: 4.345

Review 2.  An overview of tubulin inhibitors that interact with the colchicine binding site.

Authors:  Yan Lu; Jianjun Chen; Min Xiao; Wei Li; Duane D Miller
Journal:  Pharm Res       Date:  2012-07-20       Impact factor: 4.200

3.  Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.

Authors:  Casey J Maguire; Graham J Carlson; Jacob W Ford; Tracy E Strecker; Ernest Hamel; Mary Lynn Trawick; Kevin G Pinney
Journal:  Medchemcomm       Date:  2019-06-04       Impact factor: 3.597

4.  Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4.

Authors:  Andrii Malashchuk; Anton V Chernykh; Vasyl V Hurmach; Maxim O Platonov; Oleksandra Onopchenko; Sergey Zozulya; Constantin G Daniliuc; Alexey V Dobrydnev; Ivan S Kondratov; Yuriy S Moroz; Oleksandr O Grygorenko
Journal:  J Mol Struct       Date:  2020-05-10       Impact factor: 3.196

5.  Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues.

Authors:  Daniel Nascimento do Amaral; Bruno C Cavalcanti; Daniel P Bezerra; Paulo Michel P Ferreira; Rosane de Paula Castro; José Ricardo Sabino; Camila Maria Longo Machado; Roger Chammas; Claudia Pessoa; Carlos M R Sant'Anna; Eliezer J Barreiro; Lídia Moreira Lima
Journal:  PLoS One       Date:  2014-03-10       Impact factor: 3.240

Review 6.  Natural products as new antimitotic compounds for anticancer drug development.

Authors:  Carlos Roberto Koscky Paier; Sarah Sant'Anna Maranhão; Teiliane Rodrigues Carneiro; Lídia Moreira Lima; Danilo Damasceno Rocha; Renan da Silva Santos; Kaio Moraes de Farias; Manoel Odorico de Moraes-Filho; Claudia Pessoa
Journal:  Clinics (Sao Paulo)       Date:  2018-12-10       Impact factor: 2.365

7.  Substrate-Controlled Cu(OAc)2-Catalyzed Stereoselective Semi-Reduction of Alkynes with MeOH as the Hydrogen Source.

Authors:  Jiuzhong Huang; Xiaoning Li; Huiling Wen; Lu Ouyang; Nianhua Luo; Jianhua Liao; Renshi Luo
Journal:  ACS Omega       Date:  2021-04-22

Review 8.  Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review.

Authors:  Eavan C McLoughlin; Niamh M O'Boyle
Journal:  Pharmaceuticals (Basel)       Date:  2020-01-03
  8 in total

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