Literature DB >> 19879752

Identification of novel agonists of the integrin CD11b/CD18.

Mohd Hafeez Faridi1, Dony Maiguel, Constantinos J Barth, Darren Stoub, Ruth Day, Stephan Schürer, Vineet Gupta.   

Abstract

We report the identification of novel small molecule agonists of integrin CD11b/CD18, which increased, in a dose-dependent manner, the adhesion of the integrin CD11b/CD18 expressing cells to two physiologically relevant ligands: Fibrinogen and iC3b. Compound 6 showed an ex vivo EC(50) of 10.5 microM and in vitro selectivity for binding to the recombinant alphaA-domain of CD11b/CD18. In silico docking experiments suggest that the compounds recognized a hydrophobic cleft in the ligand-binding alphaA-domain, implying an allosteric mechanism of modulation of integrin affinity by this novel compound.

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Year:  2009        PMID： 19879752      PMCID： PMC2818319          DOI： 10.1016/j.bmcl.2009.10.077

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  27 in total

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Authors:  J P Xiong; R Li; M Essafi; T Stehle; M A Arnaout
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2.  Crystal structure of the extracellular segment of integrin alpha Vbeta3.

Authors:  J P Xiong; T Stehle; B Diefenbach; R Zhang; R Dunker; D L Scott; A Joachimiak; S L Goodman; M A Arnaout
Journal:  Science       Date:  2001-09-06       Impact factor: 47.728

3.  Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies.

Authors:  Clare J McCleverty; Robert C Liddington
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4.  Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.

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Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-04       Impact factor: 11.205

5.  Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy.

Authors:  Richard A Friesner; Jay L Banks; Robert B Murphy; Thomas A Halgren; Jasna J Klicic; Daniel T Mainz; Matthew P Repasky; Eric H Knoll; Mee Shelley; Jason K Perry; David E Shaw; Perry Francis; Peter S Shenkin
Journal:  J Med Chem       Date:  2004-03-25       Impact factor: 7.446

Review 6.  Integrins: bidirectional, allosteric signaling machines.

Authors:  Richard O Hynes
Journal:  Cell       Date:  2002-09-20       Impact factor: 41.582

7.  MM-GB/SA rescoring of docking poses in structure-based lead optimization.

Authors:  Cristiano R W Guimarães; Mario Cardozo
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8.  Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty.

Authors:  D I Simon; Z Dhen; P Seifert; E R Edelman; C M Ballantyne; C Rogers
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9.  Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

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Journal:  Nat Med       Date:  2001-06       Impact factor: 53.440

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  14 in total

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Authors:  Mohd Hafeez Faridi; Samia Q Khan; Wenpu Zhao; Ha Won Lee; Mehmet M Altintas; Kun Zhang; Vinay Kumar; Andrew R Armstrong; Carmelo Carmona-Rivera; Jessica M Dorschner; Abigail M Schnaith; Xiaobo Li; Yogita Ghodke-Puranik; Erica Moore; Monica Purmalek; Jorge Irizarry-Caro; Tingting Zhang; Rachael Day; Darren Stoub; Victoria Hoffmann; Shehryar Jehangir Khaliqdina; Prachal Bhargava; Ana M Santander; Marta Torroella-Kouri; Biju Issac; David J Cimbaluk; Andrew Zloza; Rajeev Prabhakar; Shashank Deep; Meenakshi Jolly; Kwi Hye Koh; Jonathan S Reichner; Elizabeth M Bradshaw; JianFeng Chen; Luis F Moita; Peter S Yuen; Wanxia Li Tsai; Bhupinder Singh; Jochen Reiser; Swapan K Nath; Timothy B Niewold; Roberto I Vazquez-Padron; Mariana J Kaplan; Vineet Gupta
Journal:  J Clin Invest       Date:  2017-03-06       Impact factor: 14.808

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Review 3.  New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.

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Journal:  Immunol Res       Date:  2013-12       Impact factor: 2.829

4.  Agonist leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers.

Authors:  Emrah Celik; Mohd Hafeez Faridi; Vinay Kumar; Shashank Deep; Vincent T Moy; Vineet Gupta
Journal:  Biophys J       Date:  2013-12-03       Impact factor: 4.033

5.  Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.

Authors:  Dony Maiguel; Mohd Hafeez Faridi; Changli Wei; Yoshihiro Kuwano; Keir M Balla; Dayami Hernandez; Constantinos J Barth; Geanncarlo Lugo; Mary Donnelly; Ali Nayer; Luis F Moita; Stephan Schürer; David Traver; Phillip Ruiz; Roberto I Vazquez-Padron; Klaus Ley; Jochen Reiser; Vineet Gupta
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6.  CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation.

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7.  Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins.

Authors:  Joanne H Reed; Manish Jain; Kristen Lee; Ekambar R Kandimalla; Mohd Hafeez Faridi; Jill P Buyon; Vineet Gupta; Robert M Clancy
Journal:  J Biol Chem       Date:  2013-02-05       Impact factor: 5.157

8.  Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.

Authors:  Mohd Hafeez Faridi; Mehmet M Altintas; Camilo Gomez; Juan Camilo Duque; Roberto I Vazquez-Padron; Vineet Gupta
Journal:  Biochim Biophys Acta       Date:  2013-02-26

9.  CD11b-Based Pre-Targeted SPECT/CT Imaging Allows for the Detection of Inflammation in Aortic Aneurysm.

Authors:  Xiaonan Zhou; Kai Zhu; Yiqiu Zhang; Yang Ming; Dai Shi; Hui Tan; Bitao Xiang; Shichao Zhu; Dengfeng Cheng; Hao Lai; Chunsheng Wang; Guobing Liu
Journal:  J Inflamm Res       Date:  2022-03-16

10.  Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα.

Authors:  Sebastian Kruss; Luise Erpenbeck; Katharina Amschler; Tabea A Mundinger; Heike Boehm; Hans-Joachim Helms; Tim Friede; Robert K Andrews; Michael P Schön; Joachim P Spatz
Journal:  ACS Nano       Date:  2013-10-04       Impact factor: 15.881
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