OBJECTIVE: We determined whether salivary cortisol levels were associated with cognitive decline at follow-up in older persons and whether this association was modified by the APOE-ε4 allele. METHODS: Within the Longitudinal Aging Study Amsterdam (LASA), a population-based prospective cohort study, 911 persons (74.5±7.2 years, 46.4% male) collected salivary cortisol in the morning and late in the evening. At baseline and after 4 years of follow-up, global cognitive functioning, verbal memory performance, and processing speed were assessed. The longitudinal associations between cortisol measures and cognitive decline were estimated using linear mixed models, adjusted for potential confounders and the modifying role of the APOE-ε4 allele was examined. RESULTS: Lower morning cortisol levels, higher evening cortisol levels, and flattened diurnal variability of cortisol levels were associated with increased risk for memory decline in APOE-ε4 carriers but not in non-carriers. CONCLUSION: Our findings suggest that in this older non-demented population APOE-ε4 carriers may be more vulnerable to the potential detrimental effect of hypothalamic-pituitary-adrenal axis dysfunction on verbal memory performance.
OBJECTIVE: We determined whether salivary cortisol levels were associated with cognitive decline at follow-up in older persons and whether this association was modified by the APOE-ε4 allele. METHODS: Within the Longitudinal Aging Study Amsterdam (LASA), a population-based prospective cohort study, 911 persons (74.5±7.2 years, 46.4% male) collected salivary cortisol in the morning and late in the evening. At baseline and after 4 years of follow-up, global cognitive functioning, verbal memory performance, and processing speed were assessed. The longitudinal associations between cortisol measures and cognitive decline were estimated using linear mixed models, adjusted for potential confounders and the modifying role of the APOE-ε4 allele was examined. RESULTS: Lower morning cortisol levels, higher evening cortisol levels, and flattened diurnal variability of cortisol levels were associated with increased risk for memory decline in APOE-ε4 carriers but not in non-carriers. CONCLUSION: Our findings suggest that in this older non-demented population APOE-ε4 carriers may be more vulnerable to the potential detrimental effect of hypothalamic-pituitary-adrenal axis dysfunction on verbal memory performance.
Authors: Eric J Lenze; David Dixon; Rose C Mantella; Peter M Dore; Carmen Andreescu; Charles F Reynolds; John W Newcomer; Meryl A Butters Journal: Int J Geriatr Psychiatry Date: 2011-06-17 Impact factor: 3.485
Authors: Davide Bruno; Jay J Nierenberg; James C Ritchie; Michael W Lutz; Nunzio Pomara Journal: Psychoneuroendocrinology Date: 2011-07-30 Impact factor: 4.905
Authors: Robert S Stawski; David M Almeida; Margie E Lachman; Patricia A Tun; Christopher B Rosnick; Teresa Seeman Journal: J Gerontol B Psychol Sci Soc Sci Date: 2011-07 Impact factor: 4.077
Authors: Eric J Lenze; Tamara Hershey; John W Newcomer; Jordan F Karp; Daniel Blumberger; Jennifer Anger; Peter Doré; David Dixon Journal: Int J Geriatr Psychiatry Date: 2014-03-14 Impact factor: 3.485
Authors: Matthew S Panizzon; Richard Hauger; Hong Xian; Eero Vuoksimaa; Kelly M Spoon; Sally P Mendoza; Kristen C Jacobson; Terrie Vasilopoulos; Brinda K Rana; Ruth McKenzie; Jeanne M McCaffery; Michael J Lyons; William S Kremen; Carol E Franz Journal: Neurobiol Aging Date: 2013-12-27 Impact factor: 4.673