| Literature DB >> 19879258 |
Yue Cheng1, Changsong Zhang, Jun Zhao, Chenyang Wang, Yun Xu, Zhipeng Han, Guocheng Jiang, Xianling Guo, Rong Li, Xinxin Bu, Mengchao Wu, Lixin Wei.
Abstract
CpG island methylator phenotype (CIMP), in which multiple genes are concurrently methylated, is an important mechanism in hepatocellular carcinoma development. We determined a hypermethylation profile in hepatocellular carcinoma (HCC). We examined the promoter methylation status of 10 genes in 60 cases of hepatocellular carcinoma (HCC), 60 cases of paired non-tumor tissues, and 6 cases of normal tissues by methylation-specific PCR. The average methylated gene numbers were significantly different between HCC and nontumor tissues (p<0.001). We found metastasis, gamma-glutamyl transpeptidase (GGT) and tumor node metastasis (TNM) stage were significantly different among patients with different CIMP status. Patients with high frequency CIMP tumors had significantly worse survival than patients with intermediate frequency or no CIMP tumors (p<0.01 and p<0.05, respectively). Our results suggested that CIMP could serve as a molecular marker of late stage and poorly prognostic HCC development. Copyright 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 19879258 DOI： 10.1016/j.yexmp.2009.10.008
Source DB: PubMed Journal: Exp Mol Pathol ISSN： 0014-4800 Impact factor: 3.362