| Literature DB >> 19879239 |
Xiaojing Lin1, Jianfang Zhou, Yonghui Zhang, Jia Wu, Fengwei Zhang, Zi Li, Ye Zhang, Shengli Bi, Yuelong Shu, Yue Wang.
Abstract
The neuraminidase inhibitor oseltamivir has been identified to have significant anti-influenza activity in clinical practice. However, its efficacy has not been verified in enough subtypes of influenza A virus, particularly, the current pandemic virus, H1N1. In vitro, using our influenza pseudotyped particle system, oseltamivir displayed significant inhibitory effects on viral NA activity and pp release. Conversely, a boosting effect on viral infection was observed, particularly with the 2009 H1N1 pp at oseltamivir concentrations above 0.025muM. Further testing on two wild 2009 H1N1 virus strains, A/California/07/09 and A/Sichuan/1/09, as well as a seasonal flu virus, A/Baoan/51/2008, confirmed these findings.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19879239 DOI： 10.1016/j.bbrc.2009.10.142
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575