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Literature DB >> 19879139

Synthesis of fluorescent C24-ceramide: evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin.

Jakub Novotný¹, Katerina Pospechová, Alexandr Hrabálek, Robert Cáp, Katerina Vávrová.

Abstract

Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo[c][1,2,5]oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools.

Entities: Chemical Disease Species

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Year: 2009 PMID： 19879139 DOI： 10.1016/j.bmcl.2009.10.047

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

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Authors: Peter Sjövall; Lisa Skedung; Sébastien Gregoire; Olga Biganska; Franck Clément; Gustavo S Luengo
Journal: Sci Rep Date: 2018-11-12 Impact factor: 4.379

2. Use of a Fluorescent Analog of Glucose (2-NBDG) To Identify Uncultured Rumen Bacteria That Take Up Glucose.

Authors: Junyi Tao; Courtney McCourt; Halima Sultana; Corwin Nelson; John Driver; Timothy J Hackmann
Journal: Appl Environ Microbiol Date: 2019-03-22 Impact factor: 4.792

3. Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct.

Authors: Kateřina Vávrová; Dominika Henkes; Kay Strüver; Michaela Sochorová; Barbora Školová; Madeleine Y Witting; Wolfgang Friess; Stephan Schreml; Robert J Meier; Monika Schäfer-Korting; Joachim W Fluhr; Sarah Küchler
Journal: J Invest Dermatol Date: 2013-09-23 Impact factor: 8.551

Synthesis of fluorescent C24-ceramide: evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin.

1. Imaging the distribution of skin lipids and topically applied compounds in human skin using mass spectrometry.

2. Use of a Fluorescent Analog of Glucose (2-NBDG) To Identify Uncultured Rumen Bacteria That Take Up Glucose.

3. Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct.

4. Synthesis and antibacterial evaluation of a new series of N-Alkyl-2-alkynyl/(E)-alkenyl-4-(1H)-quinolones.

5. A small azide-modified thiazole-based reporter molecule for fluorescence and mass spectrometric detection.

6. Topically applied ceramide accumulates in skin glyphs.

7. Serum Sphingolipid Variations Associate with Hepatic Decompensation and Survival in Patients with Cirrhosis.