| Literature DB >> 19879138 |
Abstract
Sulfur-containing 3,5-disubstituted boron dipyrromethene (Bodipy) fluorescent probes with improved water solubility were synthesized. A dicarboxylic acid derivative that can be excited by the 543 nm HeNe laser line is very soluble in aqueous solution and retains high fluorescence quantum yield of the unionizable parent molecule. Conversion of the dicarboxylic acid to the succimidyl or sulfosuccinimidyl diester produces molecules capable of labeling proteins with a bright and stable fluorescence signal.Entities:
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Year: 2009 PMID: 19879138 PMCID: PMC2837930 DOI: 10.1016/j.bmcl.2009.10.080
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN: 0960-894X Impact factor: 2.823