Literature DB >> 19878867

JAK2 gets histone H3 rolling.

Martin Sattler1, James D Griffin.   

Abstract

Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 releases the transcriptional repressor HP1alpha from chromatin, resulting in gene transcription.

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Year:  2009        PMID： 19878867     DOI： 10.1016/j.ccr.2009.10.009

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  5 in total

1.  Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling.

Authors:  Rebecca A Helmer; Marlyn Panchoo; Janet S Dertien; Suhani M Bhakta; Aveline Hewetson; Beverly S Chilton
Journal:  Mol Cell Endocrinol       Date:  2010-05-26       Impact factor: 4.102

Review 2.  Targeting JAK2 in the therapy of myeloproliferative neoplasms.

Authors:  Mamatha M Reddy; Anagha Deshpande; Martin Sattler
Journal:  Expert Opin Ther Targets       Date:  2012-02-17       Impact factor: 6.902

Review 3.  Kinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitors.

Authors:  Christine Victoria Ichim
Journal:  Stem Cells Transl Med       Date:  2014-03-05       Impact factor: 6.940

Review 4.  Deregulation of Interferon Signaling in Malignant Cells.

Authors:  Efstratios Katsoulidis; Surinder Kaur; Leonidas C Platanias
Journal:  Pharmaceuticals (Basel)       Date:  2010-02-04

5.  A polymeric nanomedicine diminishes inflammatory events in renal tubular cells.

Authors:  Alvaro C Ucero; Sergio Berzal; Carlos Ocaña-Salceda; Mónica Sancho; Mar Orzáez; Angel Messeguer; Marta Ruiz-Ortega; Jesús Egido; María J Vicent; Alberto Ortiz; Adrián M Ramos
Journal:  PLoS One       Date:  2013-01-02       Impact factor: 3.240
  5 in total

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