| Literature DB >> 19878866 |
Bin Zhao1, Qunying Lei, Kun-Liang Guan.
Abstract
Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In this issue, Zhou et al. (2009) reported that Mst1/2 ablation leads to hepatocellular carcinomas. Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent.Entities:
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Year: 2009 PMID: 19878866 DOI: 10.1016/j.ccr.2009.10.008
Source DB: PubMed Journal: Cancer Cell ISSN: 1535-6108 Impact factor: 31.743