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Literature DB >> 19878677

Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network.

Abstract

The von Hippel-Lindau (VHL) tumor suppressor gene is a protein interaction hub, controlling numerous genes implicated in tumor progression. Here we focus on structural aspects of protein interactions for a list of 35 experimentally verified protein VHL (pVHL) interactors. Using structural information and computational analysis we have located three distinct interaction interfaces (A, B, and C). Interface B is the most versatile, recognizing a refined linear motif present in 17 otherwise non-related proteins. It has been possible to distinguish compatible and exclusive interactions by relating pVHL function to interaction interfaces and subcellular localization. A novel hypothesis is presented regarding the possible function of the N-terminus as an inhibitor of pVHL function.

Entities: Disease Gene

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Year: 2009 PMID： 19878677 DOI： 10.1016/j.febslet.2009.10.070

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

12 in total

1. Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma.

Authors: Mariana Rezende Alves; Felipe Cavalcanti Carneiro; André Mourão Lavorato-Rocha; Walter Henriques da Costa; Isabela Werneck da Cunha; Stênio de Cássio Zequi; Gustavo Cardoso Guimaraes; Fernando Augusto Soares; Dirce Maria Carraro; Rafael Malagoli Rocha
Journal: Virchows Arch Date: 2014-07-16 Impact factor: 4.064

2. Association of the von Hippel-Lindau protein with AUF1 and posttranscriptional regulation of VEGFA mRNA.

Authors: Hong Xin; Julie A Brown; Changning Gong; Hao Fan; Gary Brewer; James R Gnarra
Journal: Mol Cancer Res Date: 2011-11-15 Impact factor: 5.852

3. Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance.

Authors: Caroline Razafinjatovo; Svenja Bihr; Axel Mischo; Ursula Vogl; Manuela Schmidinger; Holger Moch; Peter Schraml
Journal: BMC Cancer Date: 2016-08-17 Impact factor: 4.430

4. Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors.

Authors: Giovanni Minervini; Raffaele Lopreiato; Raissa Bortolotto; Antonella Falconieri; Geppo Sartori; Silvio C E Tosatto
Journal: Sci Rep Date: 2017-04-20 Impact factor: 4.379

5. VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma.

Authors: Caroline Fanja Razafinjatovo; Daniel Stiehl; Eva Deininger; Markus Rechsteiner; Holger Moch; Peter Schraml
Journal: Oncotarget Date: 2017-02-07

Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network.

1. Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma.

2. Association of the von Hippel-Lindau protein with AUF1 and posttranscriptional regulation of VEGFA mRNA.

3. Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance.

4. Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors.

5. VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma.

6. The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer.

7. Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein.

8. Design and analysis of a Petri net model of the Von Hippel-Lindau (VHL) tumor suppressor interaction network.

9. VHLdb: A database of von Hippel-Lindau protein interactors and mutations.

10. The E3 ubiquitin-protein ligase MDM2 is a novel interactor of the von Hippel-Lindau tumor suppressor.