OBJECTIVES: Adipose tissue-derived inflammation may contribute to metabolic alterations and eventually to the metabolic syndrome (MetS). The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons. DESIGN: Cross-sectional population-based InCHIANTI study. SUBJECTS: A total of 944 community-dwelling adults aged 65 years and older living in Tuscany, Italy. MEASUREMENTS: Obesity was defined as body mass index > or =30 kg/m2 and MetS as > or =3 of the ATP-III criteria. Circulating levels of C-reactive protein, interleukin (IL)-6, IL-1 receptor antagonist (IL-1ra), IL-18, tumour necrosis factor (TNF)-alpha R1, adiponectin, resistin and leptin were measured. Additionally, insulin resistance was determined using the homeostasis model assessment (HOMA-IR). RESULTS: The prevalence of the MetS was 32%. Both overall and abdominal obesity were significantly associated with the MetS after adjusting for inflammatory cytokines, adipokines and lifestyle factors. After adjusting for multiple confounders and HOMA-IR, IL-1ra, TNF-alpha R1 and adiponectin (P < 0.05) remained significantly associated with the MetS. Having multiple cytokines in the highest tertile increased the likelihood of having the MetS in both obese (P for trend 0.002) and non-obese persons (P for trend 0.001) independent of insulin resistance. CONCLUSIONS: Non-obese and obese individuals who develop an intense pro-inflammatory state may be more prone to develop the MetS than those with lower levels of inflammation.
OBJECTIVES: Adipose tissue-derived inflammation may contribute to metabolic alterations and eventually to the metabolic syndrome (MetS). The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obesepersons. DESIGN: Cross-sectional population-based InCHIANTI study. SUBJECTS: A total of 944 community-dwelling adults aged 65 years and older living in Tuscany, Italy. MEASUREMENTS: Obesity was defined as body mass index > or =30 kg/m2 and MetS as > or =3 of the ATP-III criteria. Circulating levels of C-reactive protein, interleukin (IL)-6, IL-1 receptor antagonist (IL-1ra), IL-18, tumour necrosis factor (TNF)-alpha R1, adiponectin, resistin and leptin were measured. Additionally, insulin resistance was determined using the homeostasis model assessment (HOMA-IR). RESULTS: The prevalence of the MetS was 32%. Both overall and abdominal obesity were significantly associated with the MetS after adjusting for inflammatory cytokines, adipokines and lifestyle factors. After adjusting for multiple confounders and HOMA-IR, IL-1ra, TNF-alpha R1 and adiponectin (P < 0.05) remained significantly associated with the MetS. Having multiple cytokines in the highest tertile increased the likelihood of having the MetS in both obese (P for trend 0.002) and non-obesepersons (P for trend 0.001) independent of insulin resistance. CONCLUSIONS:Non-obese and obese individuals who develop an intense pro-inflammatory state may be more prone to develop the MetS than those with lower levels of inflammation.
Authors: Joseph Hung; Brendan M McQuillan; Caroline M L Chapman; Peter L Thompson; John P Beilby Journal: Arterioscler Thromb Vasc Biol Date: 2005-03-24 Impact factor: 8.311
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Authors: Wiebke Greggersen; Sebastian Rudolf; Eva Fassbinder; Leif Dibbelt; Beate M Stoeckelhuber; Fritz Hohagen; Kerstin M Oltmanns; Kai G Kahl; Ulrich Schweiger Journal: Eur Arch Psychiatry Clin Neurosci Date: 2011-02-26 Impact factor: 5.270
Authors: Tamara Tchkonia; Dean E Morbeck; Thomas Von Zglinicki; Jan Van Deursen; Joseph Lustgarten; Heidi Scrable; Sundeep Khosla; Michael D Jensen; James L Kirkland Journal: Aging Cell Date: 2010-08-15 Impact factor: 9.304