OBJECTIVE: This in situ study evaluated the remineralizing potential of pit and fissure sealants containing amorphous calcium phosphate (ACP) and/or fluoride in artificially induced carious lesions on smooth enamel surfaces. MATERIAL AND METHODS:Ten volunteers who wore acrylic palatal devices were enrolled in this 5-day double-blind study and assigned to one of the following five groups: (I) demineralized enamel slab+Fluroshield (sealant with fluoride); (II) demineralized enamel slab+Aegis (sealant with ACP); (III) demineralized enamel slab+experimental sealant with fluoride (ESF); (IV) demineralized enamel slab+experimental sealant with fluoride/ACP (ACP-F); and (V) demineralized enamel slab (control). After the experimental period, the percentage of surface microhardness recovery (%SMHR) and the integrated loss of subsurface hardness (DeltaKHN) were evaluated. The concentrations of fluoride, calcium and phosphorus in enamel were also determined. RESULTS: The sealants containing ACP and/or fluoride presented a higher remineralizing capacity (%SMHR and DeltaKHN) than that of the control group. Aegis provided either more efficient or similar remineralization than the other sealants. The association between ACP and fluoride did not show a greater efficacy in the remineralization. F, Ca and P concentrations in enamel varied according to the group. CONCLUSION: The pit and fissure sealants containing ACP were able to promote remineralization of artificially induced carious lesions on smooth enamel surfaces.
RCT Entities:
OBJECTIVE: This in situ study evaluated the remineralizing potential of pit and fissure sealants containing amorphous calcium phosphate (ACP) and/or fluoride in artificially induced carious lesions on smooth enamel surfaces. MATERIAL AND METHODS: Ten volunteers who wore acrylic palatal devices were enrolled in this 5-day double-blind study and assigned to one of the following five groups: (I) demineralized enamel slab+Fluroshield (sealant with fluoride); (II) demineralized enamel slab+Aegis (sealant with ACP); (III) demineralized enamel slab+experimental sealant with fluoride (ESF); (IV) demineralized enamel slab+experimental sealant with fluoride/ACP (ACP-F); and (V) demineralized enamel slab (control). After the experimental period, the percentage of surface microhardness recovery (%SMHR) and the integrated loss of subsurface hardness (DeltaKHN) were evaluated. The concentrations of fluoride, calcium and phosphorus in enamel were also determined. RESULTS: The sealants containing ACP and/or fluoride presented a higher remineralizing capacity (%SMHR and DeltaKHN) than that of the control group. Aegis provided either more efficient or similar remineralization than the other sealants. The association between ACP and fluoride did not show a greater efficacy in the remineralization. F, Ca and P concentrations in enamel varied according to the group. CONCLUSION: The pit and fissure sealants containing ACP were able to promote remineralization of artificially induced carious lesions on smooth enamel surfaces.
Authors: Takehiko Shimizu; Bao Ho; Kathleen Deeley; Jessica Briseño-Ruiz; Italo M Faraco; Brett I Schupack; João A Brancher; Giovana D Pecharki; Erika C Küchler; Patricia N Tannure; Andrea Lips; Thays C S Vieira; Asli Patir; Mine Yildirim; Fernando A Poletta; Juan C Mereb; Judith M Resick; Carla A Brandon; Iêda M Orioli; Eduardo E Castilla; Mary L Marazita; Figen Seymen; Marcelo C Costa; José M Granjeiro; Paula C Trevilatto; Alexandre R Vieira Journal: PLoS One Date: 2012-09-24 Impact factor: 3.240
Authors: Maha Ibrahim AlGhannam; Mana'a Saleh AlAbbas; Jumanah Abdulla AlJishi; Muath Abdulrahman AlRuwaili; Jehan AlHumaid; Maria Salem Ibrahim Journal: Polymers (Basel) Date: 2022-02-17 Impact factor: 4.329