| Literature DB >> 19877705 |
Brian D Gallagher1, Benjamin R Taft, Bruce H Lipshutz.
Abstract
The combination of catalytic amounts of [(R)-DTBM-SEGPHOS]CuH in the presence of stoichiometric DEMS (diethoxymethylsilane) in toluene at room temperature leads to asymmetric reductions of 4-substituted coumarins. Several targets or their known precursors can be prepared in high yields and ee's, including the muscarine receptor antagonist (R)-tolterodine.Entities:
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Year: 2009 PMID： 19877705 DOI： 10.1021/ol9020404
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005