| Literature DB >> 19877630 |
Daniel R Fandrick1, Jonathan T Reeves, Zhulin Tan, Heewon Lee, Jinhua J Song, Nathan K Yee, Chris H Senanayake.
Abstract
The utility of propargyl diethanolamine boronates as reagents for the preparation of allenes and homopropargylic alcohols is presented. Protonolysis with TFA and electrophilic substitution with N-halosuccinimides proceeded with inversion to provide the corresponding allene in high yield and regioselectivity. Alternatively, the propargylation of aldehydes was achieved with use of the in situ generated lithiated complex.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19877630 DOI： 10.1021/ol9022529
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005