Literature DB >> 19876985

The active site of an enzyme can host both enantiomers of a racemic ligand simultaneously.

Matthias Mentel1, Wulf Blankenfeldt, Rolf Breinbauer.   

Abstract

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Year:  2009        PMID： 19876985     DOI： 10.1002/anie.200902997

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  6 in total

1.  Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor.

Authors:  Manna Huang; Yongxian Shao; Jianying Hou; Wenjun Cui; Beibei Liang; Yingchun Huang; Zhe Li; Yinuo Wu; Xinhai Zhu; Peiqing Liu; Yiqian Wan; Hengming Ke; Hai-Bin Luo
Journal:  Mol Pharmacol       Date:  2015-08-27       Impact factor: 4.436

2.  Total syntheses of dalesconol A and B.

Authors:  Scott A Snyder; Trevor C Sherwood; Audrey G Ross
Journal:  Angew Chem Int Ed Engl       Date:  2010-07-12       Impact factor: 15.336

3.  Unexpected stereochemical tolerance for the biological activity of tyroscherin.

Authors:  Hyun Seop Tae; John Hines; Ashley R Schneekloth; Craig M Crews
Journal:  Bioorg Med Chem       Date:  2011-01-19       Impact factor: 3.641

Review 4.  The significance of chirality in drug design and development.

Authors:  W H Brooks; W C Guida; K G Daniel
Journal:  Curr Top Med Chem       Date:  2011       Impact factor: 3.295

5.  First chemoenzymatic stereodivergent synthesis of both enantiomers of promethazine and ethopropazine.

Authors:  Paweł Borowiecki; Daniel Paprocki; Maciej Dranka
Journal:  Beilstein J Org Chem       Date:  2014-12-18       Impact factor: 2.883

6.  Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention.

Authors:  Nikolaus Guttenberger; Thomas Schlatzer; Mario Leypold; Sebastian Tassoti; Rolf Breinbauer
Journal:  Monatsh Chem       Date:  2017-11-30       Impact factor: 1.451
  6 in total

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