Literature DB >> 19876055

Potential utility of PPARalpha activation in the prevention of ischemic and drug-induced acute renal damage.

Francisco J Lopez-Hernandez1, José M Lopez-Novoa.   

Abstract

Acute renal failure induced by renal ischemia or drugs continues to be a relevant clinical problem. Li et al. have demonstrated that proximal tubule-restricted peroxisome proliferator-activated receptor-alpha (PPARalpha) expression in transgenic mice reduced cisplatin- and ischemia/reperfusion-induced acute renal injury. Their article suggests a role for the maintenance of free fatty acid oxidation in the proximal tubule as a mechanism of nephroprotection, as well as a potential clinical utility of PPARalpha activators in the prevention of acute renal failure.

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Year:  2009        PMID： 19876055     DOI： 10.1038/ki.2009.229

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  8 in total

1.  Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.

Authors:  Shenyang Li; Nithya Mariappan; Judit Megyesi; Brian Shank; Krishnaswamy Kannan; Sue Theus; Peter M Price; Jeremy S Duffield; Didier Portilla
Journal:  Am J Physiol Renal Physiol       Date:  2013-06-26

Review 2.  Secreted klotho and chronic kidney disease.

Authors:  Ming Chang Hu; Makoto Kuro-o; Orson W Moe
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

3.  Role of PPARα and Its Agonist in Renal Diseases.

Authors:  Ching-Feng Cheng; Hsi-Hsien Chen; Heng Lin
Journal:  PPAR Res       Date:  2010-11-08       Impact factor: 4.964

Review 4.  Peroxisomes and Kidney Injury.

Authors:  Radovan Vasko
Journal:  Antioxid Redox Signal       Date:  2016-04-22       Impact factor: 8.401

5.  Activation of PPARα by Oral Clofibrate Increases Renal Fatty Acid Oxidation in Developing Pigs.

Authors:  Yonghui He; Imad Khan; Xiumei Bai; Jack Odle; Lin Xi
Journal:  Int J Mol Sci       Date:  2017-12-08       Impact factor: 5.923

Review 6.  Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis.

Authors:  Shreekrishna Lamichane; Babita Dahal Lamichane; Sang-Mo Kwon
Journal:  Int J Mol Sci       Date:  2018-03-22       Impact factor: 5.923

7.  Pseudoginsengenin DQ Exhibits Therapeutic Effects in Cisplatin-Induced Acute Kidney Injury via Sirt1/NF-κB and Caspase Signaling Pathway without Compromising Its Antitumor Activity in Mice.

Authors:  Zeng Qi; Zhuo Li; Wei Li; Yunhe Liu; Cuizhu Wang; Hongqiang Lin; Jinping Liu; Pingya Li
Journal:  Molecules       Date:  2018-11-21       Impact factor: 4.411

8.  Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.

Authors:  Meng Zhou; Yanpeng Dai; Yong Ma; Yi Yan; Min Hua; Qi Gao; Xue Geng; Qian Zhou
Journal:  Molecules       Date:  2022-06-14       Impact factor: 4.927
  8 in total

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