Literature DB >> 19875285

Four new cytotoxic oligosaccharidic derivatives of 12-oleanene from Lysimachia heterogenea Klatt.

Xin-an Huang1, Yong-ju Liang, Xiao-ling Cai, Xiao-quan Feng, Chuan-hai Zhang, Li-wu Fu, Wen-di Deng.   

Abstract

Cytotoxicity-guided phytochemical analysis on the extract of Lysimachia heterogenea Klatt led to the isolation of 3beta,16beta-12-oleanene-3,16,23,28-tetrol (1) and its four new oligosaccharidic derivatives heterogenosides A, B, C, and D (2-5). Their structural elucidation was mainly based on NMR and mass spectral data. The time course experimental results indicated that unlike the likely lysis activity of heterogenosides B-D, heterogenoside A showed a significantly time-dependent cytotoxicity.

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Year:  2009        PMID: 19875285     DOI: 10.1016/j.bmcl.2009.10.056

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Two new triterpenoids from Lysimachia heterogenea Klatt and evaluation of their cytotoxicity.

Authors:  Xin-An Huang; Xiao-Ling Shen; Ying-Jie Hu; Ya-Ming Liu; Kang-Lun Liu; Feng-Xue Zhang; Xin-Xin Zhou
Journal:  Molecules       Date:  2011-09-20       Impact factor: 4.411

2.  Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer.

Authors:  George R Pettit; Noeleen Melody; Frank Hempenstall; Jean-Charles Chapuis; Thomas L Groy; Lee Williams
Journal:  J Nat Prod       Date:  2014-04-02       Impact factor: 4.050

  2 in total

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