Literature DB >> 19875281

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands.

Enrico Morera1, Luciano De Petrocellis, Ludovica Morera, Aniello Schiano Moriello, Alessia Ligresti, Marianna Nalli, David F Woodward, Vincenzo Di Marzo, Giorgio Ortar.   

Abstract

The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the identification of some 'dual-action' compounds targeting both FAAH and TRPV1 or TRPA1 receptors.

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Year:  2009        PMID: 19875281     DOI: 10.1016/j.bmcl.2009.09.033

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  "Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control.

Authors:  Fabiana Piscitelli; Vincenzo Di Marzo
Journal:  ACS Chem Neurosci       Date:  2012-02-27       Impact factor: 4.418

2.  Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates.

Authors:  Tyler M Rose; Christopher A Reilly; Cassandra E Deering-Rice; Clinton Brewster; Chelsea Brewster
Journal:  Bioorg Med Chem Lett       Date:  2014-10-28       Impact factor: 2.823

3.  Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.

Authors:  Jonathan Z Long; Xin Jin; Alexander Adibekian; Weiwei Li; Benjamin F Cravatt
Journal:  J Med Chem       Date:  2010-02-25       Impact factor: 7.446

Review 4.  The endocannabinoid system as a potential therapeutic target for pain modulation.

Authors:  Ahmet Ulugöl
Journal:  Balkan Med J       Date:  2014-06-01       Impact factor: 2.021

Review 5.  A structural view of ligand-dependent activation in thermoTRP channels.

Authors:  Ximena Steinberg; Carolyne Lespay-Rebolledo; Sebastian Brauchi
Journal:  Front Physiol       Date:  2014-05-05       Impact factor: 4.566

Review 6.  Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain Management.

Authors:  Natalia Malek; Katarzyna Starowicz
Journal:  Front Pharmacol       Date:  2016-08-17       Impact factor: 5.810

7.  Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis.

Authors:  Jakub Mlost; Magdalena Kostrzewa; Natalia Malek; Katarzyna Starowicz
Journal:  Int J Mol Sci       Date:  2018-01-24       Impact factor: 5.923

  7 in total

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