| Literature DB >> 19875190 |
Mohammad Kazemi Arababadi1, Reza Nosratabadi, Gholamhossein Hassanshahi, Narges Yaghini, Vahid Pooladvand, Ali Shamsizadeh, Hamid Hakimi, Reza Derakhshan.
Abstract
The impact of several environmental and genetic factors on diabetes and its complications is well documented. The present study was aimed to examine the serum levels of IL-17A and IFN-gamma as antagonistic cytokines in nephropathic and non-nephropathic type-2 diabetic patients. In this experimental study, serum samples were obtained from 180 type-2 diabetic patients, 100 nephropathic type-2 diabetic patients and 100 healthy controls. Serum levels of IL-17A and IFN-gamma was detected by ELISA. Results of this study showed that the serum level of IFN-gamma was higher in both diabetic patients (nephropathic and non-nephropathic) in comparison to the controls. In terms of IL-17A, while non-nephropathic type-2 diabetic patients showed an increased serum level of it, the other patients group had a lower serum level. Based on these findings, it can be concluded that the lower serum level of IL-17A is possibly associated with nephropathic complications of type-2 diabetes. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19875190 DOI： 10.1016/j.diabres.2009.09.027
Source DB: PubMed Journal: Diabetes Res Clin Pract ISSN： 0168-8227 Impact factor: 5.602