| Literature DB >> 19875168 |
Carlos Alberto Scrideli1, Maria Angélica Abdala Cortez, José Andres Yunes, Rosane Gomes de Paula Queiróz, Elvis Terci Valera, Juliana França da Mata, Silvia Regina Caminada Toledo, Priscila Pavoni-Ferreira, Maria Lúcia de Martino Lee, Antonio Sérgio Petrilli, Silvia Regina Brandalise, Luiz Gonzaga Tone.
Abstract
This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (P=0.04) and multivariable analysis (P=0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL. 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19875168 DOI： 10.1016/j.leukres.2009.10.007
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156