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Literature DB >> 19874068

A practical total synthesis of globo-H for use in anticancer vaccines.

Insik Jeon¹, Karthik Iyer, Samuel J Danishefsky.

Abstract

An improved synthesis of the hexasaccharide MBr1 antigen (globo-H) is reported. Enhanced efficiency in the synthesis was necessary for the scale-up production of globo-H, in order to advance globo-H-based anticancer vaccines to clinical trials. The key features of the improved synthesis include preactivation-based glycosylations and a revised iodosulfonimidation/rearrangement.

Entities: CellLine Chemical Disease Gene Species

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Year: 2009 PMID： 19874068 PMCID： PMC3016894 DOI： 10.1021/jo901682p

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

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