Literature DB >> 19873990

Alotaketals A and B, sesterterpenoids from the marine sponge Hamigera species that activate the cAMP cell signaling pathway.

Roberto Forestieri1, Catherine E Merchant, Nicole J de Voogd, Teatulohi Matainaho, Timothy J Kieffer, Raymond J Andersen.   

Abstract

The new sesterterpenoids alotaketals A (1) and B (2) have been isolated from extracts of the marine sponge Hamigera sp. collected in Papua New Guinea. Their chemical structures were elucidated by analysis of spectroscopic data. Alotaketals A and B have the unprecedented alotane carbon skeleton, and they activate the cAMP cell signaling pathway with EC(50)'s of 18 and 240 nM, respectively.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19873990     DOI： 10.1021/ol902066e

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Total synthesis and structure-activity relationship study of the potent cAMP signaling agonist (-)-alotaketal A.

Authors:  Jinhua Huang; Jessica R Yang; Jin Zhang; Jiong Yang
Journal:  Org Biomol Chem       Date:  2013-04-12       Impact factor: 3.876

2.  Total synthesis of the potent cAMP signaling agonist (-)-alotaketal A.

Authors:  Jinhua Huang; Jessica R Yang; Jin Zhang; Jiong Yang
Journal:  J Am Chem Soc       Date:  2012-05-16       Impact factor: 15.419

Review 3.  Marine pharmacology in 2009-2011: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2013-07-16       Impact factor: 5.118

4.  Sesterterpenoid and Steroid Metabolites from a Deep-Water Alaska Sponge Inhibit Wnt/β-Catenin Signaling in Colon Cancer Cells.

Authors:  Hyun Bong Park; Nguyen Quoc Tuan; Joonseok Oh; Younglim Son; Mark T Hamann; Robert Stone; Michelle Kelly; Sangtaek Oh; MinKyun Na
Journal:  Mar Drugs       Date:  2018-08-27       Impact factor: 5.118

Review 5.  Bioactive natural products from marine sponges belonging to family Hymedesmiidae.

Authors:  Asmaa Abo Elgoud Said; Basma Khalaf Mahmoud; Eman Zekry Attia; Usama Ramadan Abdelmohsen; Mostafa Ahmed Fouad
Journal:  RSC Adv       Date:  2021-04-30       Impact factor: 3.361

Review 6.  Exploring Chemical Diversity of Phorbas Sponges as a Source of Novel Lead Compounds in Drug Discovery.

Authors:  Alessia Caso; Fernanda Barbosa da Silva; Germana Esposito; Roberta Teta; Gerardo Della Sala; Laura P A Nunes Cavalcanti; Alessandra Leda Valverde; Roberto Carlos C Martins; Valeria Costantino
Journal:  Mar Drugs       Date:  2021-11-26       Impact factor: 5.118
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.