Literature DB >> 19873983

Total synthesis of (-)-huperzine A.

Takahiro Koshiba1, Satoshi Yokoshima, Tohru Fukuyama.   

Abstract

The total synthesis of (-)-huperzine A was accomplished in 23 steps from a commercially available anhydride. Our synthetic route features a facile construction of the bicyclo[3.3.1] skeleton equipped with proper functionalities to introduce the remaining substructures.

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Year:  2009        PMID： 19873983     DOI： 10.1021/ol9022408

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

Review 1.  Neurotrophic natural products: chemistry and biology.

Authors:  Jing Xu; Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-18       Impact factor: 15.336

2.  Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin.

Authors:  Julie A Pigza; Jeong-Seok Han; Aroop Chandra; Daniel Mutnick; Maren Pink; Jeffrey N Johnston
Journal:  J Org Chem       Date:  2012-12-28       Impact factor: 4.354

3.  Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation.

Authors:  Riming Yan; Zhibin Zhang; Ya Wang; Huilin Yang; Qinggui Zeng; Du Zhu
Journal:  J Ind Microbiol Biotechnol       Date:  2014-05-28       Impact factor: 3.346

4.  Pyridone annulation via tandem Curtius rearrangement/6π-electrocyclization: total synthesis of (-)-lyconadin C.

Authors:  Xiayun Cheng; Stephen P Waters
Journal:  Org Lett       Date:  2013-08-02       Impact factor: 6.005

5.  Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A.

Authors:  Shaohua Shu; Xinmei Zhao; Wenjuan Wang; Guowei Zhang; Andreea Cosoveanu; Youngjoon Ahn; Mo Wang
Journal:  World J Microbiol Biotechnol       Date:  2014-09-12       Impact factor: 3.312

Review 6.  The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses.

Authors:  Arun K Ghosh; Anindya Sarkar; Margherita Brindisi
Journal:  Org Biomol Chem       Date:  2018-02-26       Impact factor: 3.876

7.  De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A.

Authors:  Guowei Zhang; Wenjuan Wang; Xiangmei Zhang; Qianqian Xia; Xinmei Zhao; Youngjoon Ahn; Nevin Ahmed; Andreea Cosoveanu; Mo Wang; Jialu Wang; Shaohua Shu
Journal:  PLoS One       Date:  2015-03-23       Impact factor: 3.240

8.  Ethanol and methanol can improve huperzine A production from endophytic Colletotrichum gloeosporioides ES026.

Authors:  Xin-Mei Zhao; Zhang-Qian Wang; Shao-Hua Shu; Wen-Juan Wang; Hai-Jie Xu; Young-Joon Ahn; Mo Wang; Xuebo Hu
Journal:  PLoS One       Date:  2013-04-17       Impact factor: 3.240

Review 9.  The pharmacology and therapeutic potential of (-)-huperzine A.

Authors:  Maung Kyaw Moe Tun; Seth B Herzon
Journal:  J Exp Pharmacol       Date:  2012-09-05

Review 10.  Microbial acetylcholinesterase inhibitors for Alzheimer's therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery.

Authors:  Amira G Zaki; El-Sayed R El-Sayed; M Abd Elkodous; Gharieb S El-Sayyad
Journal:  Appl Microbiol Biotechnol       Date:  2020-04-13       Impact factor: 5.560
  10 in total

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