| Literature DB >> 19872556 |
M McCutcheon1, S Mudd, M Strumia, B Lucké.
Abstract
Sensitization with increasing concentrations of homologous immune serum shifts the isoelectric point of the antigens studied progressively to the alkaline side. Antigens maximally sensitized with rabbit sera have shown isoelectric points of pH 5.6 to 5.8. The globulins precipitated or salted out of the same immune sera have been isoelectric at pH 5.1 to 5.2. The combination of antigen with antibody depends of course upon specific affinities; the surface properties of the sensitized antigen, agglutination and phagocytosis depend primarily upon the properties of the sensitizing serum substances combined with and deposited on the antigen surface.Entities:
Year: 1930 PMID： 19872556 PMCID： PMC2141072 DOI： 10.1085/jgp.13.6.669
Source DB: PubMed Journal: J Gen Physiol ISSN： 0022-1295 Impact factor: 4.086