Literature DB >> 19871632

STUDIES ON THE FLEXNER GROUP OF DYSENTERY BACILLI : VI. THE DETOXIFICATION OF SHIGELLA PARADYSENTERIAE BY MEANS OF PERIODIC ACID.

W F Goebel1.   

Abstract

A method for detoxifying Type Z and sp. Newcastle Sh. paradysenteriae (Flexner) has been described. This procedure involves exposing the bacilli at pH 5.0 to 0.01 M periodic acid. Microorganisms treated with this reagent for an appropriate time interval lose approximately 90 per cent of their toxicity, yet they are capable of eliciting in experimental animals antibodies effective against the unaltered organisms.

Entities:  

Keywords:  ACID/periodic; DYSENTERY/bacilli; DYSENTERY/toxin

Mesh：

Substances：

Year:  1947        PMID： 19871632      PMCID： PMC2135711          DOI： 10.1084/jem.85.5.499

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  7 in total

1.  Studies in immunochemistry: The use of phenol and of alkali in the degradation of antigenic material isolated from Bact. dysenteriae (Shiga).

Authors:  W T Morgan; S M Partridge
Journal:  Biochem J       Date:  1941-11       Impact factor: 3.857

2.  KETENE (CH2=CO): A NEW REAGENT FOR THE DETOXIFICATION OF VACCINE.

Authors:  J T Tamura; M J Boyd
Journal:  Science       Date:  1936-01-17       Impact factor: 47.728

3.  The Detoxification by Acetylation of Soluble Antigens From Shigella dysenteriae (Shiga) and E. typhosa.

Authors:  H P Treffers
Journal:  Science       Date:  1946-03-29       Impact factor: 47.728

4.  STUDIES ON THE FLEXNER GROUP OF DYSENTERY BACILLI : IV. THE SEROLOGICAL AND TOXIC PROPERTIES OF THE SOMATIC ANTIGENS.

Authors:  E Perlman; W F Goebel
Journal:  J Exp Med       Date:  1946-08-31       Impact factor: 14.307

5.  PREPARATION AND PROPERTIES OF SHIGA TOXIN AND TOXOID.

Authors:  R J Dubos; J W Geiger
Journal:  J Exp Med       Date:  1946-07-31       Impact factor: 14.307

6.  STUDIES ON THE FLEXNER GROUP OF DYSENTERY BACILLI : II. THE CHEMICAL DEGRADATION OF THE SPECIFIC ANTIGEN OF TYPE Z SHIGELLA PARADYSENTERIAE (FLEXNER).

Authors:  F Binkley; W F Goebel; E Perlman
Journal:  J Exp Med       Date:  1945-04-01       Impact factor: 14.307

7.  TOXINS AND ANTITOXINS OF BACILLUS DYSENTERIAE SHIGA.

Authors:  P K Olitsky; I J Kligler
Journal:  J Exp Med       Date:  1920-01-01       Impact factor: 14.307
  7 in total
  3 in total

1.  [Histochemical detection of carbohydrates].

Authors:  P GEDIGK
Journal:  Klin Wochenschr       Date:  1952-12-01

2.  [Relation between the toxicity and immunogenicity of typhoid vaccines].

Authors:  H LOFFLER
Journal:  Z Hyg Infektionskr       Date:  1951

3.  The inactivation of biologically active proteins, and the virus of western equine encephalomyelitis by periodic acid.

Authors:  W F GOEBEL; P K OLITSKY; A C SAENZ
Journal:  J Exp Med       Date:  1948-05-01       Impact factor: 14.307
  3 in total

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