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Literature DB >> 19871594

DISSOCIATION OF HEMAGGLUTINATING AND ANTIBODY-MEASURING CAPACITIES OF INFLUENZA VIRUS.

Abstract

Preparations of Type B influenza virus, propagated in the embryonated egg and obtained in the form of allantoic fluid, were found after heating at 56 degrees C. for 30 minutes to retain the capacity to agglutinate erythrocytes but no longer measured specific antibody when used as antigen in titrations of serum antibody. The dissociation of the two activities suggests the presence in such virus preparations of a complex virus antigen comprising, (1) a heat-stable component which agglutinates erythrocytes and reacts primarily with specific antibody; (2) a heat-labile component reacting with a factor of normal serum which ordinarily tends to inhibit the hemagglutinating activity of influenza virus. The relation of the reagents to other known serological activities of influenza virus is being studied.

Entities: Species

Keywords: AGGLUTINATION AND AGGLUTININS/hemagglutination; ANTIGENS AND ANTIBODIES; INFLUENZA/virus; VIRUSES

Mesh：

Substances：

Year: 1947 PMID： 19871594 PMCID： PMC2135674 DOI： 10.1084/jem.85.1.1

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

2 in total

1. NEUROLOGICAL SIGNS IN MICE FOLLOWING INTRACEREBRAL INOCULATION OF INFLUENZA VIRUSES.

Authors: G Henle; W Henle
Journal: Science Date: 1944-11-03 Impact factor: 47.728

2. THE QUANTITATIVE DETERMINATION OF INFLUENZA VIRUS AND ANTIBODIES BY MEANS OF RED CELL AGGLUTINATION.

Authors: G K Hirst
Journal: J Exp Med Date: 1942-01-01 Impact factor: 14.307

2 in total

30 in total

1. [Bacterial hemagglutination. II. Nonspecific inhibition of E. coli hemagglutination].

Authors: W A COLLIER; S T WONG; J C DE MIRANDA
Journal: Antonie Van Leeuwenhoek Date: 1955 Impact factor: 2.271

2. Comparison of the experimental results obtained in the course of inactivation of non-specific inhibitors in serum by means of the haemagglutination inhibition and virus neutralization tests.

Authors: S HORVATH
Journal: Arch Gesamte Virusforsch Date: 1961

DISSOCIATION OF HEMAGGLUTINATING AND ANTIBODY-MEASURING CAPACITIES OF INFLUENZA VIRUS.

1. NEUROLOGICAL SIGNS IN MICE FOLLOWING INTRACEREBRAL INOCULATION OF INFLUENZA VIRUSES.

2. THE QUANTITATIVE DETERMINATION OF INFLUENZA VIRUS AND ANTIBODIES BY MEANS OF RED CELL AGGLUTINATION.

1. [Bacterial hemagglutination. II. Nonspecific inhibition of E. coli hemagglutination].

2. Comparison of the experimental results obtained in the course of inactivation of non-specific inhibitors in serum by means of the haemagglutination inhibition and virus neutralization tests.

3. Non-specific inhibitors of influenza viruses in normal sera.

4. [Nonspecific inhibitory factors against influenza viruses in the normal serum of guinea pigs].

5. [Homologous interference by heat-inactivated influenza-B-virus absorbed on erythrocytes].

6. [Neuraminic acid-containing glycoproteins of the cerebrospinal fluid in diseases of the nervous system].

7. [Not Available].

8. [Virus diseases in otorhinolaryngology region].

9. Recent work on the intrinsic qualities of influenza virus; somatic and genetic aspects.

10. Inhibitors of influenza virus haemagglutination in normal animal sera.